The Development of Classical Swine Fever Marker Vaccines in Recent Years.
The Development of Classical Swine Fever Marker Vaccines in Recent Years.
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DOI：
10.3390/vaccines10040603
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发表时间：
2022-04-13
期刊：
影响因子：
7.8
通讯作者：
Yi, Lin
中科院分区：
文献类型：
--
作者：
Li, Fangfang;Li, Bingke;Niu, Xinni;Chen, Wenxian;Li, Yuwan;Wu, Keke;Li, Xiaowen;Ding, Hongxing;Zhao, Mingqiu;Chen, Jinding;Yi, Lin
猪瘟是给全球养猪业造成严重经济损失的一种严重疾病，在世界范围内广泛流行。近几十年来，通过强制接种脑脊液活疫苗(C株)，脑脊液得到了有效控制。在一些国家或地区已经成功根除了这种疾病。然而，脑脊液在日本和罗马尼亚重新出现，在那里已经被根除，这引起了人们对这种疾病的更多关注。由于传统的C株疫苗不能区分接种疫苗和受感染的动物(DIVA)，这使得对抗脑脊液变得困难。标记疫苗的出现被认为是去除脑脊液污染的有效策略。本文综述了新型脑脊液标志物疫苗的研究进展，并对疫苗的设计思路和免疫效果进行了详细的概述。它还为开发新一代脑脊液疫苗和开发其他重大流行病的疫苗提供了一种方法。
Classical swine fever (CSF) is a severe disease that has caused serious economic losses for the global pig industry and is widely prevalent worldwide. In recent decades, CSF has been effectively controlled through compulsory vaccination with a live CSF vaccine (C strain). It has been successfully eradicated in some countries or regions. However, the re-emergence of CSF in Japan and Romania, where it had been eradicated, has brought increased attention to the disease. Because the traditional C-strain vaccine cannot distinguish between vaccinated and infected animals (DIVA), this makes it difficult to fight CSF. The emergence of marker vaccines is considered to be an effective strategy for the decontamination of CSF. This paper summarizes the progress of the new CSF marker vaccine and provides a detailed overview of the vaccine design ideas and immunization effects. It also provides a methodology for the development of a new generation of vaccines for CSF and vaccine development for other significant epidemics.
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影响因子：
3.7
作者：
Graham SP;Everett HE;Haines FJ;Johns HL;Sosan OA;Salguero FJ;Clifford DJ;Steinbach F;Drew TW;Crooke HR
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