The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis.
The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis.
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表达CD4+CD25高T调节细胞的CD127LOW与HTLV-1感染中的人类T淋巴营养性病毒类型1（HTLV-1）型病毒型和HTLV-1相关的骨髓性骨髓性痉挛/热带痉挛性帕帕拉斯（HTLV-1）的频率成反比。
DOI：
10.1186/1471-2172-9-41
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发表时间：
2008-07-29
期刊：
影响因子：
3
通讯作者：
Kallas, Esper G.
中科院分区：
文献类型：
--
作者：
Michaelsson, Jakob;Barbosa, Hugo Marcelo R.;Jordan, Kimberley A.;Chapman, Joan M.;Brunialti, Milena K. C.;Neto, Walter Kleine;Nukui, Youko;Sabino, Ester C.;Chieia, Marco Antonio;Bulle Oiliveira, Acary Souza;Nixon, Douglas F.;Kallas, Esper G.
CD 4 + CD 25 high调节性T（TReg）细胞调节抗原特异性T细胞应答，并且可以抑制抗病毒免疫。在HTLV-1感染中，已经描述了TReg细胞介导的HTLV-1-tax抑制FOXP 3表达的功能的选择性降低。本研究的目的是评估HTLV-1无症状携带者和HTLV-1相关神经系统疾病（HAM/TSP）患者中TReg细胞的频率和表型，并与T细胞活化指标相关。我们能够证实HTLV-I驱动活化、自发IFNγ产生和CD 4 + T细胞增殖。我们还观察到与健康对照相比，HAM/TSP患者受试者中CTLA-4+ TReg细胞（CD 4 + CD 25 high T细胞）的比例显著较低。Ki-67表达仅与HAM/TSP中CTLA-4+ TReg细胞的频率呈负相关，尽管Ki-67表达与健康对照受试者中CD 127低TReg细胞的百分比呈负相关。最后，CD 127低TReg细胞的比例与HTLV-1前病毒载量呈负相关。综上所述，结果表明，TReg细胞可能在HAM/TSP患者中被破坏，这可以解释显著的细胞活化、自发细胞因子产生和CD 4 + T细胞增殖，特别是那些表达CD 25 highCD 127 low表型的T细胞。TReg细胞代表了HTLV-1相关神经系统疾病患者治疗干预的潜在靶点。
CD4+CD25high regulatory T (TReg) cells modulate antigen-specific T cell responses, and can suppress anti-viral immunity. In HTLV-1 infection, a selective decrease in the function of TReg cell mediated HTLV-1-tax inhibition of FOXP3 expression has been described. The purpose of this study was to assess the frequency and phenotype of TReg cells in HTLV-1 asymptomatic carriers and in HTLV-1-associated neurological disease (HAM/TSP) patients, and to correlate with measures of T cell activation. We were able to confirm that HTLV-I drives activation, spontaneous IFNγ production, and proliferation of CD4+ T cells. We also observed a significantly lower proportion of CTLA-4+ TReg cells (CD4+CD25high T cells) in subjects with HAM/TSP patients compared to healthy controls. Ki-67 expression was negatively correlated to the frequency of CTLA-4+ TReg cells in HAM/TSP only, although Ki-67 expression was inversely correlated with the percentage of CD127low TReg cells in healthy control subjects. Finally, the proportion of CD127low TReg cells correlated inversely with HTLV-1 proviral load. Taken together, the results suggest that TReg cells may be subverted in HAM/TSP patients, which could explain the marked cellular activation, spontaneous cytokine production, and proliferation of CD4+ T cells, in particular those expressing the CD25highCD127low phenotype. TReg cells represent a potential target for therapeutic intervention for patients with HTLV-1-related neurological diseases.
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CD127表达与FOXP3和人类CD4+ T Reg细胞的抑制功能成反比。
DOI：
10.1084/jem.20060772
发表时间：
2006-07-10
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
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DOI：
10.1073/pnas.96.7.3848
发表时间：
1999-03-30
影响因子：
11.1
作者：
Jeffery, KJM;Usuku, K;Bangham, CRM
通讯作者：
Bangham, CRM
影响因子：
4.4
作者：
Kozako, Tomohiro;Arima, Naomichi;Sonoda, Shunro
通讯作者：
Sonoda, Shunro
影响因子：
3.7
作者：
Daenke, S;Kermode, AG;Bangham, CRM
通讯作者：
Bangham, CRM
影响因子：
11.4
作者：
Good, LF;Maggirwar, SB;Sun, SC
通讯作者：
Sun, SC