Influence of brain-derived neurotrophic factor and apolipoprotein E genetic variants on hemispheric and lateral ventricular volume of young healthy adults.
Influence of brain-derived neurotrophic factor and apolipoprotein E genetic variants on hemispheric and lateral ventricular volume of young healthy adults.
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DOI：
10.1111/j.1601-5215.2011.00546.x
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发表时间：
2011-06
影响因子：
3.8
通讯作者：
Kornhuber J
中科院分区：
文献类型：
--
作者：
Sidiropoulos C;Jafari-Khouzani K;Soltanian-Zadeh H;Mitsias P;Alexopoulos P;Richter-Schmidinger T;Reichel M;Lewczuk P;Doerfler A;Kornhuber J
脑源性神经营养因子（BDNF）和载脂蛋白E（ApoE）被认为与多种神经过程有关，包括细胞生长、对伤害性刺激的恢复和突触可塑性。BDNF蛋白中密码子66处的瓦尔至Met的取代与多种神经精神疾病相关。ApoE 4等位基因被认为是晚发性阿尔茨海默病的危险因素，但其对年轻人的影响尚不清楚。我们试图研究这两种多态性对年轻健康成年人半球和侧脑室容积的影响。使用高分辨率磁共振成像测量了144名年龄在19-35岁之间的健康个体的半球和侧脑室容积，并将数据与BDNF和ApoE基因型相关。BDNF和ApoE基因型与半球或侧脑室容积无相关性。这些结果表明，这是不可能的，无论是BDNF Val 66 Met或ApoE多态性发挥任何显着的影响半球或侧脑室容积。然而，不能排除混杂上位性遗传效应以及所用体积方法的相对不敏感性。需要进行进一步的成像分析，以更好地确定BDNF Val 6 Met和Apoe多态性对年轻健康成年人大脑结构的任何遗传影响。
Brain-derived neurotrophic factor (BDNF) and apolipoprotein E (ApoE) are thought to be implicated in a variety of neuronal processes, including cell growth, resilience to noxious stimuli and synaptic plasticity. A Val to Met substitution at codon 66 in the BDNF protein has been associated with a variety of neuropsychiatric conditions. The ApoE4 allele is considered a risk factor for late-onset Alzheimer’s disease, but its effects on young adults are less clear. We sought to investigate the effects of those two polymorphisms on hemispheric and lateral ventricular volumes of young healthy adults. Hemispheric and lateral ventricular volumes of 144 healthy individuals, aged 19–35 years, were measured using high resolution magnetic resonance imaging and data were correlated with BDNF and ApoE genotypes. There were no correlations between BDNF or ApoE genotype and hemispheric or lateral ventricular volumes. These findings indicate that it is unlikely that either the BDNF Val66Met or ApoE polymorphisms exert any significant effect on hemispheric or lateral ventricular volume. However, confounding epistatic genetic effects as well as relative insensitivity of the volumetric methods used cannot be ruled out. Further imaging analyses are warranted to better define any genetic influence of the BDNF Val6Met and ApoE polymorphism on brain structure of young healthy adults.
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影响因子：
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通讯作者：
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