Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons.
Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons.
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DOI：
10.1016/j.neuron.2020.09.028
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发表时间：
2020-12-23
期刊：
影响因子：
16.2
通讯作者：
Plotkin JL
中科院分区：
文献类型：
--
作者：
Prager EM;Dorman DB;Hobel ZB;Malgady JM;Blackwell KT;Plotkin JL
皮质纹状体突触整合在背侧纹状体的纹状体（斑块）和基质隔室之间分配，允许对行为的离散方面进行区室化控制。尽管这种组织的重要性，目前还不清楚如何区室特定的纹状体输出动态实现，特别是考虑到新的证据，传入重叠是实质性的。我们发现，多巴胺相反的形状反应收敛兴奋性输入在小鼠纹状体和基质纹状体多刺投射神经元（SPN）。突触后D1多巴胺受体的激活促进了持久的突触诱发的"向上状态"在基质SPN的产生，但反对它在纹状体，这是更兴奋的基础条件下。多巴胺能调制的差异介导的，部分是由树突状电压门控钙通道（VGCC）：药理学操纵的L型VGCC逆转室特异性反应D1受体激活。这些结果支持了一种新的机制，选择纹状体电路组件，波动水平的多巴胺转移的平衡，特定的隔室纹状体输出。Prager等人表明，多巴胺促进小鼠直接通路基质SPN中树突诱发的"上升状态"的维持，但在纹状体中与之相反。这需要突触后D1受体，并涉及L型Ca2+通道的差异参与。这些发现揭示了多巴胺的波动可能限制特定隔室纹状体输出的机制。
Corticostriatal synaptic integration is partitioned among striosome (patch) and matrix compartments of the dorsal striatum, allowing compartmentalized control of discrete aspects of behavior. Despite the significance of such organization, it’s unclear how compartment-specific striatal output is dynamically achieved, particularly considering new evidence that overlap of afferents is substantial. We show that dopamine oppositely shapes responses to convergent excitatory inputs in mouse striosome and matrix striatal spiny projection neurons (SPNs). Activation of postsynaptic D1 dopamine receptors promoted the generation of long-lasting synaptically-evoked “up-states” in matrix SPNs but opposed it in striosomes, which were more excitable under basal conditions. Differences in dopaminergic modulation were mediated, in part, by dendritic voltage-gated calcium channels (VGCCs): pharmacological manipulation of L-type VGCCs reversed compartment-specific responses to D1 receptor activation. These results support a novel mechanism for the selection of striatal circuit components, where fluctuating levels of dopamine shift the balance of compartment-specific striatal output. Prager et al. show that dopamine promotes the maintenance of dendritically-evoked “up-states” in mouse direct pathway matrix SPNs, but opposes it in striosomes. This requires postsynaptic D1 receptors, and involves differential engagement of L-type Ca2+ channels. These findings reveal a mechanism where fluctuations in dopamine may constrain compartment-specific striatal output.
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影响因子：
3.7
作者：
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通讯作者：
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通讯作者：
Costa, Rui M.
DOI：
10.1073/pnas.1704893114
发表时间：
2017-09-05
影响因子：
11.1
作者：
Du, Kai;Wu, Yu-Wei;Kotaleski, Jeanette Hellgren
通讯作者：
Kotaleski, Jeanette Hellgren