Drilling K-wires, what about the osteocytes? An experimental study in rabbits.
Drilling K-wires, what about the osteocytes? An experimental study in rabbits.
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DOI：
10.1007/s00402-007-0382-z
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发表时间：
2008-01
影响因子：
2.3
通讯作者：
Kon M
中科院分区：
文献类型：
--
作者：
Franssen BB;van Diest PJ;Schuurman AH;Kon M
骨细胞在骨坏死中的功能长期以来被低估。最近有人提出骨细胞凋亡导致强烈的破骨细胞骨吸收。因此，钻孔导致的骨细胞死亡可能会增加克氏针松动的风险。我们体内研究的目的是评估观察骨细胞消失所需的最短钻孔时间，并测量钻道周围空骨细胞腔隙的距离与插入时间的关系，直接以及将克氏针 (K-) 钢丝钻入兔子的股骨和胫骨后 4 周。将带有套管针的克氏针（长度 70 毫米，厚度 0.6 毫米）钻入 14 只新西兰白兔 [平均体重 2.81 公斤（2.66–3.09 公斤）] 的股骨和胫骨。六只兔子在手术后 (t = 0) 被终止，八只兔子在手术后 4 周 (t = 4) 被终止。终止后，从股骨和胫骨切下苏木精和曙红染色的切片，直到钻孔可见。在光学显微镜下评估切片中钻孔周围的骨细胞腔隙中是否存在骨细胞。在手术后立即和术后 4 周，分别有 50% 和 87% 的病例克氏针周围的所有骨细胞陷窝都是空的。尤其是在 t = 0 和 t = 4 时，骨细胞消失，钻孔时间分别为 37 秒（P = 0.011）和 27 秒（P = 0.008）。此外，在 t = 0 (P = 0.008) 和 t = 4 (P = 0.000) 时，钻孔周围空骨细胞腔隙的距离与时间之间存在显着正相关。虽然只研究了不带冷却的钻孔，但在临床实践中不使用冷却的情况下，短钻孔时间可能会防止骨细胞消失，就像经皮克氏针插入的情况一样。
The function of osteocytes regarding osteonecrosis has been underestimated for a long time. Recently it has been suggested that apoptosis of osteocytes results in strong osteoclastic bone resorption. Death of osteocytes due to drilling may therefore increase the risk of K-wire loosening. The purposes of our in vivo study were to assess the minimal drill time needed to notice disappearance of osteocytes and to measure the distance of the empty osteocyte lacunae surrounding the drill tract in relation with the insertion time, directly and 4 weeks after drilling Kirschner (K-) wires into the femur and tibia of rabbits. Trocar tipped K-wires (70 mm length and 0.6 mm thickness) were drilled into the femur and tibia of 14 New Zealand white rabbits [mean body weight 2.81 kg (2.66–3.09 kg)]. Six rabbits were terminated following surgery (t = 0) and eight rabbits were terminated 4 weeks (t = 4) after surgery. Following termination, hematoxylin and eosin stained sections were cut from femur and tibia until the drill hole was visible. The sections were evaluated under a light microscope for the presence or absence of osteocytes in osteocyte lacunae surrounding the drill holes. All osteocyte lacunae were empty around the K-wires in 50 and 87% of the cases, directly and 4 weeks after the surgery, respectively. The osteocytes disappeared especially beyond a drilling time of 37 s (P = 0.011) and 27 s (P = 0.008) at t = 0 and t = 4, respectively. Furthermore, a significantly positive correlation was seen between the distances of the empty osteocyte lacunae surrounding the drill holes in relation with time at t = 0 (P = 0.008) and t = 4 (P = 0.000). Although only drilling without cooling was studied, short drilling times may prevent the disappearance of osteocytes in case cooling is not used in clinical practice as is the case in percutaneous K-wire insertion.
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影响因子：
2.8
作者：
Li, G;Dickson, GR;Simpson, H
通讯作者：
Simpson, H
影响因子：
4.1
作者：
MaejimaIkeda, A;Aoki, M;Kumegawa, M
通讯作者：
Kumegawa, M
DOI：
10.1016/s0300-9785(82)80020-3
发表时间：
1982-01-01
期刊：
INTERNATIONAL JOURNAL OF ORAL SURGERY
影响因子：
--
作者：
ERIKSSON, A;ALBREKTSSON, T;MCQUEEN, D
通讯作者：
MCQUEEN, D
DOI：
10.2106/00004623-197254020-00008
发表时间：
1972-01-01
影响因子：
5.3
作者：
MATTHEWS, LS;HIRSCH, C
通讯作者：
HIRSCH, C
DOI：
10.1016/j.bbrc.2005.06.211
发表时间：
2005-10-07
影响因子：
3.1
作者：
Gu, GL;Mulari, M;Väänänen, HK
通讯作者：
Väänänen, HK