Nuclear overexpression of metastasis-associated protein 1 correlates significantly with poor survival in nasopharyngeal carcinoma.
Nuclear overexpression of metastasis-associated protein 1 correlates significantly with poor survival in nasopharyngeal carcinoma.
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转移相关蛋白 1 的核过度表达与鼻咽癌的低生存率显着相关
DOI：
10.1186/1479-5876-10-78
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发表时间：
2012-04-26
影响因子：
7.4
通讯作者：
Ma J
中科院分区：
文献类型：
--
作者：
Li WF;Liu N;Cui RX;He QM;Chen M;Jiang N;Sun Y;Zeng J;Liu LZ;Ma J
背景转移相关蛋白1（Metastasis-associated protein 1，MTA 1）与多种恶性肿瘤的预后不良有关。本研究旨在探讨MTA 1在鼻咽癌（NPC）中的表达及其预后价值。方法采用免疫组织化学方法检测208例NPC石蜡包埋标本中MTA 1的表达。考克斯回归分析用于计算风险比（HR），95%置信区间（CI），并确定独立的预后因素，和递归分割分析被用来创建一个决策tree.Results48.6%（101/208）的NPC组织中观察到MTA 1的核过表达。MTA 1的过表达与胃癌的N分期（P= 0.02）、临床分期（P= 0.04）、远处转移（P< 0.01）和死亡（P= 0.01）呈正相关。此外，MTA 1的核过表达与较差的无远处转移生存期（DMFS;P<0.01）和较差的总生存期（OS;P< 0.01）显著相关。MTA 1在II期鼻咽癌患者中具有预后意义，但在III期或IV期鼻咽癌患者中无预后意义。多变量分析表明，MTA 1的核过表达与较差的DMFS（HR，2.05; 95% CI，1.13-3.72;P= 0.02）和较差的OS（HR，1.98; 95% CI，1.09-3.59;P= 0.03）独立相关。使用递归分割分析，鼻咽癌患者可分为低，中，高风险的远处转移和死亡，根据临床分期，年龄和MTA 1 expression.ConclusionThe研究结果表明，核MTA 1过表达相关显着较差的DFS和较差的OS在鼻咽癌。MTA 1有可能成为一种新的鼻咽癌预后生物标志物。
BackgroundMetastasis-associated protein 1 (MTA1) has been associated with poor prognosis in several malignant carcinomas. The purpose of this study was to investigate the expression and prognostic value of MTA1 in nasopharyngeal carcinoma (NPC).MethodsMTA1 expression was assessed using immunohistochemistry in paraffin-embedded tumor specimens from 208 untreated NPC patients. Cox regression analysis was used to calculate the hazard ratio (HR), 95% confidence interval (CI) and identify independent prognostic factors, and recursive partitioning analysis was used to create a decision tree.ResultsNuclear overexpression of MTA1 was observed in 48.6% (101/208) of the NPC tissues. Nuclear overexpression of MTA1 correlated positively with N classification (P= 0.02), clinical stage (P= 0.04), distant metastasis (P< 0.01) and death (P= 0.01). Additionally, nuclear overexpression of MTA1 correlated significantly with poorer distant metastasis-free survival (DMFS;P<0.01) and poorer overall survival (OS;P< 0.01). MTA1 had prognostic significance in NPC patients with stage II disease, but not stage III or IV disease. Multivariate analysis demonstrated that nuclear overexpression of MTA1 was independently associated with poorer DMFS (HR, 2.05; 95% CI, 1.13–3.72;P= 0.02) and poorer OS (HR, 1.98; 95% CI, 1.09–3.59;P= 0.03). Using recursive partitioning analysis, the NPC patients could be classified with a low, intermediate or high risk of distant metastasis and death, on the basis of clinical stage, age and MTA1 expression.ConclusionThe results of this study suggest that nuclear overexpression of MTA1 correlates significantly with poorer DMFS and poorer OS in NPC. MTA1 has potential as a novel prognostic biomarker in NPC.
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影响因子：
16
作者：
Xue, YT;Wong, JM;Wang, WD
通讯作者：
Wang, WD
影响因子：
11.2
作者：
Hofer, MD;Kuefer, R;Rubin, MA
通讯作者：
Rubin, MA
影响因子：
3.8
作者：
Martin, MD;Hilsenbeck, SG;O'Connell, P
通讯作者：
O'Connell, P
DOI：
10.1016/j.ijom.2008.05.020
发表时间：
2008-11-01
影响因子：
2.4
作者：
Kawasaki, G.;Yanamoto, S.;Mizuno, A.
通讯作者：
Mizuno, A.
MTA1的表达促进了PANC-1胰腺癌细胞的运动和侵袭性。
影响因子：
8.8
作者：
Hofer, M D;Menke, A;Genze, F;Gierschik, P;Giehl, K
通讯作者：
Giehl, K