Taiwan Biobank: A rich biomedical research database of the Taiwanese population.
Taiwan Biobank: A rich biomedical research database of the Taiwanese population.
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DOI：
10.1016/j.xgen.2022.100197
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发表时间：
2022-11-09
期刊：
影响因子：
--
通讯作者：
Lin, Yen-Feng
中科院分区：
文献类型：
--
作者：
Feng, Yen-Chen Anne;Chen, Chia-Yen;Chen, Tzu-Ting;Kuo, Po-Hsiu;Hsu, Yi-Hsiang;Yang, Hwai-, I;Chen, Wei J.;Su, Ming-Wei;Chu, Hou-Wei;Shen, Chen-Yang;Ge, Tian;Huang, Hailiang;Lin, Yen-Feng
台湾生物银行（TWB）是一项正在进行的前瞻性研究，研究对象为台湾20-70岁的150，000人。通过结构化访谈和身体测量，在招募和随访访视时收集每位知情参与者的表型综合列表。从血液和尿液样本中生成生物标志物和遗传数据。我们在这里提出的TWB的遗传数据质量，人口结构和家庭关系，其中主要包括汉族血统的概述，并强调其重要属性和遗传研究结果迄今。目前正在与台湾超过25年的国民健康保险数据库和其他登记处进行链接，以丰富表型谱，并进行深入和纵向的遗传调查。TWB为东亚的生物医学和公共卫生研究提供了最大的生物库资源之一，通过与其他生物库的合作研究，有助于我们了解全球人群健康和疾病的遗传基础。台湾生物库（TWB）是一项前瞻性人群研究，拥有超过15万人，在以汉族为基础的队列中收集了丰富的表型和遗传数据。未来与国家健康登记系统的连接将使纵向遗传研究成为可能。等人描述了台湾一个令人印象深刻的生物医学资源，它测量了超过150，000个个体的广泛特征沿着基因组成。这一资源使大规模的流行病学和遗传学调查成为可能，并丰富了人类基因组研究中的人口多样性。
The Taiwan Biobank (TWB) is an ongoing prospective study of >150,000 individuals aged 20–70 in Taiwan. A comprehensive list of phenotypes was collected for each consented participant at recruitment and follow-up visits through structured interviews and physical measurements. Biomarkers and genetic data were generated from blood and urine samples. We present here an overview of TWB’s genetic data quality, population structure, and familial relationship, which consists of predominantly Han Chinese ancestry, and highlight its important attributes and genetic findings thus far. A linkage to Taiwan’s National Health Insurance database of >25 years and other registries is underway to enrich the phenotypic spectrum and enable deep and longitudinal genetic investigations. TWB provides one of the largest biobank resources for biomedical and public health research in East Asia that will contribute to our understanding of the genetic basis of health and disease in global populations through collaborative studies with other biobanks. Taiwan Biobank (TWB) is a prospective population study with >150,000 individuals Rich phenotypic and genetic data were collected in the Han-Chinese-based cohort Future linkage to national health registries will empower longitudinal genetic studies TWB studies contribute to population diversity in global genetics research Feng. et al. describe an impressive biomedical resource in Taiwan that measures a wide range of characteristics in >150,000 individuals along with their genetic makeup. This resource enables large-scale epidemiological and genetic investigations and enriches population diversity in human genomic research.
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Calo, Eliezer;Wysocka, Joanna
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Wysocka, Joanna
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通讯作者：
Chang, Howard Y.