Impaired hippocampal ripple-associated replay in a mouse model of schizophrenia.
Impaired hippocampal ripple-associated replay in a mouse model of schizophrenia.
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DOI：
10.1016/j.neuron.2013.09.014
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发表时间：
2013-10-16
期刊：
影响因子：
16.2
通讯作者：
Tonegawa S
中科院分区：
文献类型：
--
作者：
Suh J;Foster DJ;Davoudi H;Wilson MA;Tonegawa S
精神分裂症的认知症状可能是由于神经回路的信息处理功能受损所致。我们记录了前脑特异性敲除突触可塑性介导磷酸酶钙调磷酸酶的自由行为小鼠海马体中的神经活动，这些小鼠先前显示出行为和认知异常，再现了精神分裂症的症状。钙调磷酸酶敲除（KO）在清醒休息期间显示出2.5倍的锐波涟漪（SWR）事件丰度增加，并且KO中的单个单位在SWR事件中过度活跃。然而，对单位活动的成对测量显示，在SWR事件中，位置细胞的顺序再激活在KO中完全消失。由于经历后清醒休息期间的这种关系与学习、工作记忆和随后的记忆巩固有关，我们的研究结果为信息加工受损提供了一种新的机制，可能导致精神分裂症患者的认知障碍。
The cognitive symptoms of schizophrenia presumably result from impairments of information processing in neural circuits. We recorded neural activity in the hippocampus of freely behaving mice with a forebrain-specific knockout of the synaptic plasticity-mediating phosphatase calcineurin, that were previously shown to exhibit behavioral and cognitive abnormalities, recapitulating the symptoms of schizophrenia. Calcineurin knockout (KO) exhibited a 2.5-fold increase in the abundance of sharp-wave ripple (SWR) events during awake resting periods and single units in KO were overactive during SWR events. Pairwise measures of unit activity, however, revealed that the sequential reactivation of place cells during SWR events was completely abolished in KO. Since this relationship during the post-experience awake rest periods has been implicated in learning, working memory and subsequent memory consolidation, our findings provide a novel mechanism underlying impaired information processing, potentially resulting in the cognitive impairments in schizophrenia.
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DOI：
10.1073/pnas.89.10.4363
发表时间：
1992-05-15
影响因子：
11.1
作者：
DUDEK, SM;BEAR, MF
通讯作者：
BEAR, MF
影响因子：
64.8
作者：
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DOI：
10.1073/pnas.1432927100
发表时间：
2003-07-22
影响因子：
11.1
作者：
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通讯作者：
Tonegawa, S
影响因子：
25
作者：
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通讯作者：
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影响因子：
25
作者：
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通讯作者：
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