Cone mosaic development in the goldfish retina is independent of rod neurogenesis and differentiation

Cone mosaic development in the goldfish retina is independent of rod neurogenesis and differentiation
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金鱼视网膜中的视锥细胞镶嵌发育独立于视杆神经发生和分化

DOI:
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发表时间:
2000
期刊:
The Journal of comparative neurology
影响因子:
--
通讯作者:
D. L. Stenkamp
D. L. Stenkamp
中科院分区:
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文献类型:
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作者:
Jun Wan;D. L. Stenkamp

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金鱼的视网膜显示出一种特有的锥状光感受器排列,根据光谱表型,锥状光感受器以刻板的顺序发育。有人认为,硬骨鱼类中最早分化的光感受器,即杆状光感受器,可能对锥状镶嵌体的发育起指导作用。首先通过检查视锥亚型特异性标志物相对于视杆视蛋白的表达模式,然后通过杀死产生视杆的细胞并检查在不存在新视杆的情况下形成的视锥镶嵌来测试该假设。我们发现,虽然有潜力的发展锥和有丝分裂后立即杆之间的相互作用,锥镶嵌图案形成的作用是不太可能的。神经学比较杂志423:227-242,2000.© 2000 Wiley利斯公司
The goldfish retina displays a characteristic arrangement of cone photoreceptors that develop in a stereotyped sequence according to spectral phenotype. It has been suggested that the earliest differentiating photoreceptor in the teleost, the rod photoreceptor, might play an instructive role in development of the cone mosaic. This hypothesis was tested, first by examining the expression pattern of a cone subtype‐specific marker with respect to that of rod opsin, and then by killing the cells that generate rods and examining the cone mosaic that formed in the absence of new rods. We find that, although there is potential for interactions between developing cones and immediately postmitotic rods, a role for such interactions in cone mosaic pattern formation is not likely. J. Comp. Neurol. 423:227–242, 2000. © 2000 Wiley‐Liss, Inc.
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