Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study.
Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study.
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DOI：
10.1371/journal.pone.0061466
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Giwercman A
中科院分区：
文献类型：
--
作者：
Bobjer J;Katrinaki M;Tsatsanis C;Lundberg Giwercman Y;Giwercman A
在老年男性中，低度全身性炎症（LGSI）以及雄激素缺乏与包括心血管疾病（CVD）在内的几种病理学相关。我们想调查低睾酮水平是否与年轻时LGSI的生物标志物有关，在CVD或其他全身性疾病的任何并发表现之前。巢式横断面研究。从一项正在进行的男性生育力低下研究中随机选择40名生化性腺功能减退（n = 20）或性腺功能正常（n = 20）的男性（平均年龄37岁，SD =4.3）和20名年龄匹配的对照。 受试者包括不育夫妇中的男性伴侣，其中也存在精子浓度低于正常的情况。进行了血样采集、访谈和人体测量。评估血清睾酮、LH、雌二醇、SHBG和21种LGSI标记物水平。在21种炎症标志物中，巨噬细胞炎症蛋白1-α（MIP 1a）（α =-0.025; p = 0.028），1-β（MIP 1B）（α =-0.015; p = 0.049）和肿瘤坏死因子α（TNF α）（α =-0.015; p = 0.040）与总睾酮（TT）水平呈负相关。 MIP 1a（α =-1.95; p = 0.001）和TNF α（α =-0.95; p = 0.014）与计算的游离睾酮（cFT）水平呈负相关。 与TT和cFT水平正常的男性相比，TT（平均比值1.61; p = 0.006）和cFT（平均比值1.58; p = 0.007）低于正常水平的男性中TNF a水平更高。 此外，MIP 1a水平在TT水平低于正常水平的男性中更高（平均比值1.84; p = 0.030）。 低水平的睾酮可能已经在年轻时与LGSI相关，这可能是男性性腺功能减退症不良健康后果的机制的一部分。
Low grade systemic inflammation (LGSI) as well as androgen deficiency has in older men been associated with several pathologies, including cardiovascular disease (CVD). We wanted to investigate whether low testosterone levels are linked to biomarkers of LGSI already in young age, before any concurrent manifestations of CVD or other systemic diseases. Nested cross-sectional study. Forty subfertile biochemically hypogonadal (n = 20) or eugonadal (n = 20) men (mean age 37 years, SD = 4.3) and 20 age-matched controls were randomly selected from an ongoing study on male subfertility. Subjects comprised male partners in infertile couples in whom also subnormal sperm concentration was present. Blood sampling, interviews, and anthropometric measures were undertaken. Serum levels of testosterone, LH, estradiol, SHBG, and 21 LGSI-markers were assessed. Among 21 inflammatory markers, macrophage inflammatory protein 1-alpha (MIP1a) (ß = −0.025; p = 0.028), 1-beta (MIP1B) (ß = −0.015; p = 0.049) and tumor necrosis factor alpha (TNFa) (ß = −0.015; p = 0.040) showed negative association to total testosterone (TT) levels. MIP1a (ß = −1.95; p = 0.001) and TNFa (ß = −0.95; p = 0.014) showed negative association to calculated free testosterone (cFT) levels. Compared to men with normal TT and cFT levels, TNFa levels were higher in men with subnormal levels of TT (mean ratio 1.61; p = 0.006) and cFT (mean ratio 1.58; p = 0.007). Also, MIP1a levels were higher in men with subnormal levels of TT (mean ratio 1.84; p = 0.030). Subnormal testosterone may already in young age associate to LGSI, which might be a part of the mechanism underlying adverse health outcomes of male hypogonadism.
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