Demystifying functional role of cocaine- and amphetamine-related transcript (CART) peptide in control of energy homeostasis: A twenty-five year expedition.
Demystifying functional role of cocaine- and amphetamine-related transcript (CART) peptide in control of energy homeostasis: A twenty-five year expedition.
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可卡因和安非他明相关转录物（CART）肽在能量稳态控制中的神秘功能作用：25年的探险。
DOI：
10.1016/j.peptides.2021.170534
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发表时间：
2021-06
期刊：
影响因子：
3
通讯作者：
de Lartigue G
中科院分区：
文献类型：
--
作者：
Singh A;de Araujo AM;Krieger JP;Vergara M;Ip CK;de Lartigue G
可卡因和苯丙胺相关转录本(CART)是一种最先在大鼠大脑纹状体发现的神经肽。后来，CART肽(CARTp)的遗传序列和功能在多种哺乳动物中被发现是保守的。自发现以来的25年里，CART mRNA(Cartpt)的表达在中枢和外周神经系统中得到了广泛的报道，这突显了它在多种生理功能中的作用。在这里，我们回顾CARTp的定位和功能，因为它与能量动态平衡有关。我们总结了中枢和外周Cartpt在代谢状态下的表达变化，并利用可用的大型数据集来进一步了解Cartpt表达迷走神经细胞的解剖及其在肠道中的表达模式。此外，我们概述了CARTp作为厌食信号的作用及其对能量消耗和体重控制的影响，以及来自药理学和转基因动物研究的见解。随后，我们讨论了CARTp在肥胖的病理生理学中的作用，并回顾了在寻找CARTp信号的候选受体方面的重要新进展。总之，CARTp的研究领域最近取得了快速和实质性的进展，我们回顾了将CARTp作为阻止肥胖流行的潜在治疗靶点的案例。
Cocaine- and amphetamine-related transcript (CART) is a neuropeptide first discovered in the striatum of the rat brain. Later, the genetic sequence and function of CART peptide (CARTp) was found to be conserved among multiple mammalian species. Over the 25 years, since its discovery, CART mRNA (Cartpt) expression has been reported widely throughout the central and peripheral nervous systems underscoring its role in diverse physiological functions. Here, we review the localization and function of CARTp as it relates to energy homeostasis. We summarize the expression changes of central and peripheral Cartpt in response to metabolic states and make use of available large data sets to gain additional insights into the anatomy of the Cartpt expressing vagal neurons and their expression patterns in the gut. Furthermore, we provide an overview of the role of CARTp as an anorexigenic signal and its effect on energy expenditure and body weight control with insights from both pharmacological and transgenic animal studies. Subsequently, we discuss the role of CARTp in the pathophysiology of obesity and review important new developments towards identifying a candidate receptor for CARTp signalling. Altogether, the field of CARTp research has made rapid and substantial progress recently, and we review the case for considering CARTp as a potential therapeutic target for stemming obesity epidemic.
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DOI：
10.1124/jpet.105.091678
发表时间：
2005-12-01
影响因子：
3.5
作者：
Couceyro, PR;Evans, C;Bannon, AW
通讯作者：
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影响因子：
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作者：
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影响因子：
25
作者：
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DOI：
10.1152/ajpregu.2001.281.6.r1862
发表时间：
2001-12-01
影响因子：
2.8
作者：
Aja, S;Sahandy, S;Moran, TH
通讯作者：
Moran, TH
影响因子：
2.5
作者：
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