Pretreatment platelet count as a predictor for survival and distant metastasis in nasopharyngeal carcinoma patients.
Pretreatment platelet count as a predictor for survival and distant metastasis in nasopharyngeal carcinoma patients.
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治疗前血小板计数作为鼻咽癌患者生存和远处转移的预测因子
DOI：
10.3892/ol.2015.2872
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发表时间：
2015-03
期刊：
影响因子：
2.9
通讯作者：
Xia YF
中科院分区：
文献类型：
--
作者：
Chen YP;Chen C;Mai ZY;Gao J;Shen LJ;Zhao BC;Chen MK;Chen G;Yan F;Huang TY;Xia YF
本研究的目的是探讨不同的预处理血小板（PLT）计数对鼻咽癌（NPC）患者接受同步放化疗（CCRT）或单纯放疗（RT）的治疗结果的预后价值。共有1,501例NPC患者入组本研究，其中412例接受CCRT，1,089例接受RT。CCRT组和RT组的PLT计数临界点分别为150和300×109/l，PLT计数分为3组：低（PLT≤150×109/l）、中度（150× 109/l ~ 300 ×109/l）。为了确定总生存期（OS）的独立预测因素，采用考克斯比例风险模型确定CCRT和RT患者的局部-区域无复发生存期（LRFS）和无远处转移生存期（DMFS）率。此外，单变量和多变量分析表明，与中等PLT计数相比，低PLT计数是CCRT患者OS率的独立不利预后因素[风险比（HR），2.024; 95%置信区间（CI），1.165-3.516]，高PLT计数是CCRT患者OS和DMFS率的独立不利预后因素（OS：HR，1.742; 95%CI，1.090-2.786; DFMS：HR，2.110; 95%CI，1.084-4.108）和RT（OS：HR，1.740; 95%CI，1.283-2.362; DMFS：HR，2.819; 95%CI，1.766-4.497）患者。与低PLT计数相比，高PLT计数与RT患者的DMFS率差显著独立相关（P=0.025; HR，2.454; 95%CI，1.121-5.372）。因此，本研究表明，低和高血小板计数可能是有用的指标鼻咽癌患者接受放射治疗的生存和远处转移。
The aim of the present study was to investigate the prognostic value of different pretreatment platelet (PLT) counts on the treatment outcome in nasopharyngeal carcinoma (NPC) patients receiving concurrent chemoradiotherapy (CCRT) or radiotherapy (RT) alone. A total of 1,501 NPC patients, including 412 receiving CCRT and 1,089 receiving RT, were enrolled in the present study. The PLT count cut-off points for the CCRT and RT groups were 150 and 300×109/l, respectively, and the PLT counts were categorized it into three groups: Low (PLT≤150×109/l), moderate (150×109/l300×109/l). To identify independent predictors of overall survival (OS), the Cox proportional hazards model was used to determine local-regional recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS) rates in the CCRT and RT patients. Furthermore, univariate and multivariate analysis indicated that compared with a moderate PLT count, a low PLT count was an independent unfavorable prognostic factor for OS rate in CCRT patients [hazard ratio (HR), 2.024; 95% confidence interval (CI), 1.165–3.516], and a high PLT count was an independent unfavorable prognostic factor for OS and DMFS rates in CCRT (OS: HR, 1.742; 95% CI, 1.090–2.786; DFMS: HR, 2.110; 95%CI, 1.084–4.108) and RT (OS: HR, 1.740; 95%CI, 1.283–2.362; DMFS: HR, 2.819; 95% CI, 1.766–4.497) patients. Compared with a low PLT count, a high PLT count was significantly and independently associated with a poor DMFS rate in the RT patients (P=0.025; HR, 2.454; 95% CI, 1.121–5.372). Therefore, the present study indicates that low and high PLT counts may be useful indicators of survival and distant metastasis in NPC patients who have undergone radiation treatment.
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影响因子：
2.6
作者：
Dominguez, Ismael;Crippa, Stefano;Fernandez-del Castillo, Carlos
通讯作者：
Fernandez-del Castillo, Carlos
影响因子：
--
作者：
Qiu, Miao-zhen;Xu, Rui-hua;Jiang, Wen-qi
通讯作者：
Jiang, Wen-qi
DOI：
10.1073/pnas.94.2.663
发表时间：
1997-01-21
影响因子：
11.1
作者：
Mohle, R;Green, D;Rafii, S
通讯作者：
Rafii, S
影响因子：
7.3
作者：
Pipili-Synetos, E;Papadimitriou, E;Maragoudakis, ME
通讯作者：
Maragoudakis, ME
影响因子：
45.3
作者：
Fang, Fu-Min;Tsai, Wen-Ling;Lee, Chien-Hung
通讯作者：
Lee, Chien-Hung