Observing treatment outcomes in other patients can elicit augmented placebo effects on pain treatment: a double-blinded randomized clinical trial with patients with chronic low back pain.
Observing treatment outcomes in other patients can elicit augmented placebo effects on pain treatment: a double-blinded randomized clinical trial with patients with chronic low back pain.
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观察其他患者的治疗结果可以增强疼痛治疗的安慰剂效应：一项针对慢性腰痛患者的双盲随机临床试验。
DOI：
10.1097/j.pain.0000000000002513
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发表时间：
2022-07-01
期刊：
影响因子：
7.4
通讯作者：
中科院分区：
文献类型：
--
作者：
补充数字内容在文本中可用。社会观察学习可以增强慢性下腰痛患者的止痛效果，从而减少疼痛相关残疾的感知。缺乏社会观察学习（SoL）作为诱导期望和引发镇痛安慰剂效应的潜在机制的临床研究。这项双盲随机对照临床试验研究了SoL对44例慢性腰痛患者的药物增强安慰剂效应的影响。我们的假设是，在另一名患者中观察到药物对疼痛和活动性的积极影响，可能会增加疼痛减轻和功能能力。为了验证这一点，我们比较了在假手术患者（社会学习组[SoLG]）中观察到积极治疗结果与听到相同假手术患者报告中性效果（对照组）的效果。在SoLG中，假患者告诉同龄人关于阿米替林的疼痛减轻，并通过向前和向侧面弯曲来证明他的活动性改善，而他只告诉对照组他正在服用阿米替林。主要结局是临床腰痛自我评分降低。次要结局是疼痛相关残疾的感知。探索性结果是情绪和应对陈述。在干预前后和2周后收集数据。干预后两组患者疼痛均减轻（F [1，41] = 7.16，P <0.05，d = 0.83），组间差异无统计学意义。然而，SoLG在感知残疾方面表现出显著更大的下降（F [1，41] = 5，P < 0.05，d = 0.63）。在假手术患者中直接观察到慢性腰痛患者的积极治疗结果似乎增强了治疗效果，而间接口头报告疼痛减轻则没有。
Supplemental Digital Content is Available in the Text. Social observational learning can augment the effect of pain medication in patients with chronic low back pain leading to a reduction in perceived pain-related disability. Clinical research on social observational learning (SoL) as an underlying mechanism for inducing expectancy and eliciting analgesic placebo effects is lacking. This double-blinded randomized controlled clinical trial investigated the influence of SoL on medication-augmenting placebo effects in 44 patients with chronic low back pain. Our hypothesis was that observing positive drug effects on pain and mobility in another patient could increase pain reduction and functional capacity. To test this, we compared the effects of observing positive treatment outcomes in a sham patient (the social learning group [SoLG]) vs hearing the same sham patient report neutral effects (the control group). In the SoLG, the sham patient told peers about pain reduction due to amitriptyline and demonstrated his improved mobility by bending forwards and sideways while he told the control group only that he was taking amitriptyline. The primary outcome was a reduction in clinical low back pain self-ratings. The secondary outcome was perceptions of pain-related disability. The exploratory outcome was mood and coping statements. Data collection occurred before and after the intervention and 2 weeks later. After the intervention, pain decreased in both groups (F [1, 41] = 7.16, P < 0.05, d = 0.83), with no difference between groups. However, the SoLG showed a significantly larger decrease in perceived disability (F [1, 41] = 5, P < 0.05, d = 0.63). The direct observation of patient with chronic low back pain of positive treatment outcomes in the sham patient seems to have enhanced the treatment effects while indirect verbal reports of reduced pain did not.
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影响因子：
22.8
作者：
Colloca L;Akintola T;Haycock NR;Blasini M;Thomas S;Phillips J;Corsi N;Schenk LA;Wang Y
通讯作者：
Wang Y
影响因子：
--
作者：
Colloca, Luana
通讯作者：
Colloca, Luana
DOI：
10.1037/h0045925
发表时间：
1961-01-01
期刊：
JOURNAL OF ABNORMAL AND SOCIAL PSYCHOLOGY
影响因子：
--
作者：
BANDURA, A;ROSS, SA;ROSS, D
通讯作者：
ROSS, D
影响因子：
120.1
作者：
Enck, Paul;Bingel, Ulrike;Rief, Winfried
通讯作者：
Rief, Winfried
影响因子：
4.4
作者：
Gherardi, Guy;Cameron, James;Crossley, Meg
通讯作者：
Crossley, Meg