Inflammatory and Other Biomarkers: Role in Pathophysiology and Prediction of Gestational Diabetes Mellitus.

Inflammatory and Other Biomarkers: Role in Pathophysiology and Prediction of Gestational Diabetes Mellitus.
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DOI:
10.3390/ijms160613442
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发表时间:
2015-06-11
影响因子:
5.6
通讯作者:
Teede HJ
Teede HJ
中科院分区:
生物学2区
文献类型:
--
作者:
Abell SK;De Courten B;Boyle JA;Teede HJ

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了解病理生理学和确定母亲在主要妊娠并发症的风险是至关重要的有效预防和最佳管理。然而,在目前的产前护理中,对并发症的病理生理认识有限。在妊娠期糖尿病(GDM)中,风险预测主要基于产妇病史和临床危险因素,可能无法最佳地识别高危妊娠。因此,广泛建议进行全面筛查。在此,我们将通过对GDM及炎症标志物、脂肪因子、内皮功能、脂质等生物标志物的文献梳理,加深对GDM病理生理学的认识,探讨GDM的风险预测,以指导GDM的预防和治疗。
Understanding pathophysiology and identifying mothers at risk of major pregnancy complications is vital to effective prevention and optimal management. However, in current antenatal care, understanding of pathophysiology of complications is limited. In gestational diabetes mellitus (GDM), risk prediction is mostly based on maternal history and clinical risk factors and may not optimally identify high risk pregnancies. Hence, universal screening is widely recommended. Here, we will explore the literature on GDM and biomarkers including inflammatory markers, adipokines, endothelial function and lipids to advance understanding of pathophysiology and explore risk prediction, with a goal to guide prevention and treatment of GDM.
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