Metabolic syndrome, insulin resistance and systemic inflammation as risk factors for reduced lung function in Korean nonsmoking males.
Metabolic syndrome, insulin resistance and systemic inflammation as risk factors for reduced lung function in Korean nonsmoking males.
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DOI：
10.3346/jkms.2010.25.10.1480
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发表时间：
2010-10
影响因子：
4.5
通讯作者：
Sung KC
中科院分区：
文献类型：
--
作者：
Lim SY;Rhee EJ;Sung KC
本研究旨在评估肺功能与胰岛素抵抗（IR）、全身炎症和代谢综合征（MetS）的相关性。在9,581名表面健康的非吸烟男性成年人中，测量肺功能、空腹血糖、胰岛素、血脂和血清高敏C反应蛋白（hs-CRP）水平，并使用稳态模型评估（HOMA）评估IR。MetS的存在根据AHA/NHLBI标准定义。代谢综合征的患病率为19.3%。调整混杂因素后，限制性排除型MetS的优势比为1.55（95%可信区间为1.12-2.14），阻塞性排除型MetS的优势比为1.39（0.66-2.94）。当受试者根据FVC或FEV 1（%预测值[pred]）的四分位数分为4组时，HOMA-IR随FVC或FEV 1（%预测值[pred]）降低而显著增加。FVC或FEV 1四分位数最低的个体hs-CRP水平最高。随着FVC或FEV 1（%预测值[pred]）四分位数的降低，MetS的患病率升高。腹部肥胖、hs-CRP和HOMA-IR是最低FVC和FEV 1（%预测值[pred]）的独立预测因子，即使在调整混杂因素后也是如此。这些结果表明，MetS，IR和全身炎症是非吸烟韩国男性肺功能降低的重要危险因素。
The aim of this study was done to assess the association of lung function with insulin resistance (IR), systemic inflammation, and metabolic syndrome (MetS). In 9,581 apparently healthy non-smoking male adults, pulmonary function, fasting glucose, insulin, lipid profiles and serum high-sensitivity C-reactive protein (hs-CRP) levels were measured, and homeostatic model assessment (HOMA) was used to assess IR. The presence of MetS was defined according to the AHA/NHLBI criteria. The prevalence of MetS was 19.3%. The odds ratio of MetS for restrictive ventilatory pattern was 1.55 (95% confidence interval, 1.12-2.14), and that for obstructive ventilatory pattern was 1.39 (0.66-2.94) after adjustment for confounders. When subjects were divided in 4 groups according to quartiles of FVC or FEV1 (% predicted [pred]), HOMA-IR significantly increased as the FVC or FEV1 (% predicted [pred]) decreased. Individuals in the lowest FVC or FEV1 quartile had the highest hs-CRP level. Prevalence of MetS increased as FVC or FEV1 (% predicted [pred]) quartiles decreased. The abdominal obesity, hs-CRP and HOMA-IR were the independent predictors for the lowest FVC and FEV1 (% predicted [pred]) even after adjustment for confounders. These results indicate that MetS, IR, and systemic inflammation are important risk factors for reduced lung function in nonsmoking Korean males.
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