Sensory neurons expressing the atypical olfactory receptor guanylyl cyclase D are required for the acquisition of odor preferences by mice in diverse social contexts.
Sensory neurons expressing the atypical olfactory receptor guanylyl cyclase D are required for the acquisition of odor preferences by mice in diverse social contexts.
复制标题
表达非典型嗅觉受体鸟类环酶D的感觉神经元才能通过各种社会环境中小鼠获取气味偏好。
DOI：
10.1016/j.physbeh.2020.113150
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发表时间：
2020-12-01
影响因子：
2.9
通讯作者：
Munger SD
中科院分区：
文献类型：
--
作者：
Zimmerman AD;Nagy CR;Munger SD
动物利用社会交流从同种动物那里学习重要信息，从而指导适当的行为选择。例如，在食物偏好的社会传播（STFP）过程中，表达非典型嗅觉受体鸟苷酸环化酶D（GC-D+ OSN）的小鼠嗅觉感觉神经元（OSN）检测到的同种化学信息素促进受体动物获得食物偏好，从而降低摄入被毒素或病原体污染的食物的风险。然而，目前尚不清楚 GC-D+ OSN 是否介导在此特定背景之外的偏好学习。在这里，我们报告说，成年小鼠和幼年小鼠获得气味偏好都需要 GC-D+ OSN，并且对于有条件的厌恶气味可以形成 GC-D 依赖性偏好。我们使用两项选择的嗅觉行为测试来评估成年 Gucy2d +/+、+/- 和 -/− 小鼠的气味偏好，这些小鼠在活体同种社会调查期间或在幼崽哺乳期间遇到新气味以及 GC-D+ OSN 刺激（鸟苷素家族肽）。 Gucy2d +/+ 和+/- 小鼠（表达功能性GC-D），但Gucy2d -/− 同窝小鼠，成功地获得了对任何这些行为范式中所显示的气味的偏好。小鼠甚至可以对它们最近形成条件性厌恶的气味产生依赖于 GC-D 的偏好。总之，这些结果表明，GC-D+ OSN 在不同的社会和体验环境以及不同的生命阶段介导社会传播的气味偏好的获得。
Animals use social communication to learn important information from conspecifics that can guide appropriate behavioral choices. For example, during the social transmission of food preference (STFP), conspecific semiochemicals detected by mouse olfactory sensory neurons (OSNs) expressing the atypical olfactory receptor guanylyl cyclase D (GC-D+ OSNs) promote the acquisition of food preferences in the recipient animal, mitigating the risk of ingesting food contaminated with toxins or pathogens. However, it is unclear if GC-D+ OSNs mediate preference learning outside this specific context. Here, we report that GC-D+ OSNs are required for the acquisition of odor preferences by both adult and juvenile mice, and that GC-D-dependent preference could be formed for conditionally aversive odors. We used a two-choice olfactory behavioral test to assess odor preferences in adult Gucy2d +/+, +/− and −/− mice that encountered novel odors together with GC-D+ OSN stimuli (guanylin family peptides), during social investigation of a live conspecific, or during suckling as pups. Gucy2d +/+ and +/− mice (which express functional GC-D), but not Gucy2d −/− littermates, successfully acquire a preference for the demonstrated odor in any of these behavioral paradigms. Mice could even acquire a GC-D-dependent preference for odors to which they had recently formed a conditioned aversion. Together, these results demonstrate that GC-D+ OSNs mediate the acquisition of socially-transmitted odor preferences in different social and experiential contexts and at different life stages.
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