Leukocyte mitochondrial DNA copy number in blood is not associated with major depressive disorder in young adults.
Leukocyte mitochondrial DNA copy number in blood is not associated with major depressive disorder in young adults.
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血液中白细胞线粒体 DNA 拷贝数与年轻人的重度抑郁症无关
DOI：
10.1371/journal.pone.0096869
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
He Y;Tang J;Li Z;Li H;Liao Y;Tang Y;Tan L;Chen J;Xia K;Chen X
背景重性抑郁障碍（Major Depression Disorder，MDD）是世界范围内导致残疾的主要原因，具有明显的遗传易感性.线粒体可能在MDD中起作用，因此线粒体DNA（mtDNA）已被建议作为这种疾病的可能生物标志物。我们旨在测试是否外周血白细胞mtDNA拷贝数与MDD在年轻adult.MethodsA病例对照研究进行了210例MDD患者和217名健康对照（HC）。用定量聚合酶链反应（qPCR）方法测定线粒体DNA拷贝数。抑郁症的严重程度进行了评估，由汉密尔顿-17抑郁量表（HDRS-17）。结果我们发现，MDD患者和HC之间的mtDNA拷贝数没有显着差异，但功率分析表明，我们的样本量有足够的权力来检测的差异。线粒体DNA拷贝数与临床特征无明显相关性结论白细胞线粒体DNA拷贝数与MDD的发病无关，但这并不意味着我们可以排除线粒体参与疾病的可能性。mtDNA是否可以作为MDD的生物标志物还需要进一步的研究。
BackgroundMajor depressive disorder (MDD) is the leading cause of disability worldwide, and has significant genetic predisposition. Mitochondria may have a role in MDD and so mitochondrial DNA (mtDNA) has been suggested as a possible biomarker for this disease. We aimed to test whether the mtDNA copy number of peripheral blood leukocytes is related to MDD in young adults.MethodsA case-control study was conducted with 210 MDD patients and 217 healthy controls (HC). The mtDNA copy number was measured by quantitative polymerase chain reaction (qPCR) method. Depression severity was assessed by the Hamilton-17 Depression Rating Scale (HDRS-17).ResultsWe found no significant differences in mtDNA copy number between MDD patients and HC, though the power analysis showed that our sample size has enough power to detect the difference. There were also no significant correlations between mtDNA copy number and the clinical characteristics (such as age, age of onset, episodes, Hamilton Depression Rating Scale (HDRS) score and Global Assessment of Function Scale (GAF) score) in MDD patients.ConclusionOur study suggests that leukocyte mtDNA copy number is unlikely to contribute to MDD, but it doesn’t mean that we can exclude the possibility of involvement of mitochondria in the disease. Further studies are required to elucidate whether mtDNA can be a biomarker of MDD.
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