Overview of the genetics of major depressive disorder.
Overview of the genetics of major depressive disorder.
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DOI：
10.1007/s11920-010-0150-6
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发表时间：
2010-12
影响因子：
6.7
通讯作者：
Lohoff, Falk W.
中科院分区：
文献类型：
--
作者：
Lohoff, Falk W.
重性抑郁障碍（MDD）是一种常见的精神疾病，具有较高的发病率和死亡率.尽管在过去的几十年里进行了深入的研究，但抑郁症的神经生物学基础和病理生理学仍然未知。遗传因素在MDD的发展中起着重要作用，如家庭、双胞胎和收养研究所示，并可能揭示有关疾病机制的重要信息。本文介绍了精神病遗传学领域的最新进展，重点是MDD。早期的双生子研究，连锁研究和关联研究进行了讨论。本文综述了全基因组关联研究的最新发现，并讨论了未来的研究方向。尽管所有的努力，到目前为止，没有一个单一的遗传变异已被确定为大大增加抑郁症的风险。预计遗传变异对总体疾病风险的影响很小，多种遗传因素与环境因素结合可能是MDD发展所必需的。未来的大规模研究需要解剖这种复杂的表型，并确定参与MDD病因学的途径。
Major depressive disorder (MDD) is a common psychiatric illness with high levels of morbidity and mortality. Despite intensive research during the past several decades, the neurobiological basis and pathophysiology of depressive disorders remain unknown. Genetic factors play important roles in the development of MDD, as indicated by family, twin, and adoption studies, and may reveal important information about disease mechanisms. This article describes recent developments in the field of psychiatric genetics, with a focus on MDD. Early twin studies, linkage studies, and association studies are discussed. Recent findings from genome-wide association studies are reviewed and future directions discussed. Despite all efforts, thus far, no single genetic variation has been identified to increase the risk of depression substantially. Genetic variants are expected to have only small effects on overall disease risk, and multiple genetic factors in conjunction with environmental factors are likely necessary for the development of MDD. Future large-scale studies are needed to dissect this complex phenotype and to identify pathways involved in the etiology of MDD.
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影响因子：
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作者：
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DOI：
10.1073/pnas.0335669100
发表时间：
2003-03-04
影响因子：
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作者：
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通讯作者：
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