Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications.

Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications.
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DOI:
10.1007/s11154-010-9134-4
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发表时间:
2010-03
影响因子:
8.2
通讯作者:
Vita, Joseph A.
Vita, Joseph A.
中科院分区:
医学2区
文献类型:
--
作者:
Tabit, Corey E.;Chung, William B.;Hamburg, Naomi M.;Vita, Joseph A.

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心血管疾病是糖尿病的主要并发症,需要改进预防和治疗策略。内皮功能障碍参与糖尿病动脉粥样硬化的发病机制和临床表现。本文综述了内皮功能障碍与糖尿病相关的证据,并对其机制进行了实验研究。然后,我们讨论了这些研究对糖尿病患者心血管疾病的当前管理和预防和治疗的新方法的意义。
Cardiovascular disease is a major complication of diabetes mellitus, and improved strategies for prevention and treatment are needed. Endothelial dysfunction contributes to the pathogenesis and clinical expression of atherosclerosis in diabetes mellitus. This article reviews the evidence linking endothelial dysfunction to human diabetes mellitus and experimental studies that investigated the responsible mechanisms. We then discuss the implications of these studies for current management and for new approaches for the prevention and treatment of cardiovascular disease in patients with diabetes mellitus.
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