The attenuation of dysfunctional emotional processing with stimulant medication: an fMRI study of adolescents with ADHD.
The attenuation of dysfunctional emotional processing with stimulant medication: an fMRI study of adolescents with ADHD.
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DOI：
10.1016/j.pscychresns.2011.02.005
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发表时间：
2011-09-30
影响因子：
11.3
通讯作者：
Nagel BJ
中科院分区：
文献类型：
--
作者：
Posner J;Maia TV;Fair D;Peterson BS;Sonuga-Barke EJ;Nagel BJ
ADHD的功能性神经影像学研究主要集中在认知控制的神经相关方面。然而，对于许多患有多动症的青少年来说，情绪不稳定是该疾病的一个重要临床特征。我们的目的是确定与情绪不稳定性相关的神经基质，这些神经基质与认知控制障碍不同，并评估兴奋剂对这些基质的影响。我们使用功能性磁共振成像（fMRI）来评估患有（N=15）和非（N=15） ADHD的青少年在分别执行涉及认知控制和情绪处理的Stroop任务的认知和情感版本时的神经活动。患有多动症的参与者以一种平衡的方式接受了服用和停用兴奋剂药物的扫描。在控制认知控制差异的情况下，我们发现在情绪性Stroop任务中，与对照组相比，患有ADHD的青少年在内侧前额叶皮层（mPFC）表现出非典型活动。兴奋剂将mPFC的活动减弱到与对照组相当的水平。
Functional neuroimaging studies of ADHD have focused on the neural correlates of cognitive control. However, for many youths with ADHD, emotional lability is an important clinical feature of the disorder. We aimed to identify the neural substrates associated with emotional lability that were distinct from impairments in cognitive control and to assess the effects that stimulants have on those substrates. We used functional magnetic resonance imaging (fMRI) to assess neural activity in adolescents with (N=15) and without (N=15) ADHD while they performed cognitive and emotional versions of the Stroop task that engage cognitive control and emotional processing, respectively. The participants with ADHD were scanned both on and off stimulant medication in a counterbalanced fashion. Controlling for differences in cognitive control, we found that during the emotional Stroop task, adolescents with ADHD as compared with controls demonstrated atypical activity in the medial prefrontal cortex (mPFC). Stimulants attenuated activity in the mPFC to levels comparable with controls.
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DOI：
10.1207/s15374424jccp2901_4
发表时间：
2000-03-01
期刊：
JOURNAL OF CLINICAL CHILD PSYCHOLOGY
影响因子：
--
作者：
Maedgen, JW;Carlson, CL
通讯作者：
Carlson, CL
影响因子：
3.3
作者：
Drevets, Wayne C.;Savitz, Jonathan
通讯作者：
Savitz, Jonathan
DOI：
10.1098/rstb.1996.0125
发表时间：
1996-10-29
影响因子：
6.3
作者：
Damasio, AR
通讯作者：
Damasio, AR
影响因子：
14.8
作者：
Bush, George;Whalen, Paul J.;Rauch, Scott L.
通讯作者：
Rauch, Scott L.
影响因子：
1.9
作者：
Kratochvil, C. J.;Faries, D.;Swindle, R.
通讯作者：
Swindle, R.