Horizontal Transfer of Malignant Traits and the Involvement of Extracellular Vesicles in Metastasis.
Horizontal Transfer of Malignant Traits and the Involvement of Extracellular Vesicles in Metastasis.
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DOI：
10.3390/cells12121566
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发表时间：
2023-06-06
期刊：
影响因子：
6
通讯作者：
Lorico, Aurelio
中科院分区：
文献类型：
--
作者：
Arena, Goffredo O.;Forte, Stefano;Abdouh, Mohamed;Vanier, Cheryl;Corbeil, Denis;Lorico, Aurelio
关键词：
转移是绝大多数癌症死亡的原因，但大多数治疗努力都集中在靶向和中断肿瘤生长，而不是削弱转移过程。传统上，癌症转移归因于肿瘤细胞从原发肿瘤通过血液和淋巴循环扩散到远处器官。彻底了解转移过程对于开发新的治疗策略以提高癌症生存率至关重要。自从一百多年前佩吉特最初提出“种子和土壤”假说以来，各种替代理论和新的参与者不断被提出。特别是，癌细胞释放的细胞外囊泡（EVs）及其被邻近细胞或不同解剖部位摄取的作用已被探索。在这里，我们将概述和讨论这些替代理论，并强调ev相关生物分子的水平转移可能是导致细胞转化和诱导转移的主要事件。我们还将重点介绍最近发现的ev将其货物运送到受体细胞核的细胞内途径，这是新型抗转移策略的潜在靶点。
Metastases are responsible for the vast majority of cancer deaths, yet most therapeutic efforts have focused on targeting and interrupting tumor growth rather than impairing the metastatic process. Traditionally, cancer metastasis is attributed to the dissemination of neoplastic cells from the primary tumor to distant organs through blood and lymphatic circulation. A thorough understanding of the metastatic process is essential to develop new therapeutic strategies that improve cancer survival. Since Paget’s original description of the “Seed and Soil” hypothesis over a hundred years ago, alternative theories and new players have been proposed. In particular, the role of extracellular vesicles (EVs) released by cancer cells and their uptake by neighboring cells or at distinct anatomical sites has been explored. Here, we will outline and discuss these alternative theories and emphasize the horizontal transfer of EV-associated biomolecules as a possibly major event leading to cell transformation and the induction of metastases. We will also highlight the recently discovered intracellular pathway used by EVs to deliver their cargoes into the nucleus of recipient cells, which is a potential target for novel anti-metastatic strategies.
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影响因子：
--
作者：
Budczies J;von Winterfeld M;Klauschen F;Bockmayr M;Lennerz JK;Denkert C;Wolf T;Warth A;Dietel M;Anagnostopoulos I;Weichert W;Wittschieber D;Stenzinger A
通讯作者：
Stenzinger A
影响因子：
5.9
作者：
Valcz G;Buzás EI;Szállási Z;Kalmár A;Krenács T;Tulassay Z;Igaz P;Molnár B
通讯作者：
Molnár B
DOI：
10.1016/j.bbrc.2015.03.172
发表时间：
2015-05-22
影响因子：
3.1
作者：
Ban, Jae-Jun;Lee, Mijung;Kim, Manho
通讯作者：
Kim, Manho
影响因子：
4.7
作者：
Abdouh, Mohamed;Tabah, Roger;Arena, Goffredo Orazio
通讯作者：
Arena, Goffredo Orazio
影响因子：
4.7
作者：
Arena, Goffredo Orazio;Arena, Vincenzo;Abdouh, Mohamed
通讯作者：
Abdouh, Mohamed