Antiviral Immunity and Virus-Mediated Antagonism in Disease Vector Mosquitoes.
Antiviral Immunity and Virus-Mediated Antagonism in Disease Vector Mosquitoes.
复制标题
DOI：
10.1016/j.tim.2017.12.005
复制
发表时间：
2018-05
影响因子：
15.9
通讯作者：
Myles KM
中科院分区：
文献类型：
--
作者：
Samuel GH;Adelman ZN;Myles KM
已有100多种病原体与人类和/或动物疾病有关，这些病原体横跨多个病毒家族，被广泛称为“节肢动物传播病毒(虫媒病毒)”。这些病毒在自然界中持续传播，包括在易感脊椎动物和无脊椎动物宿主中交替复制。总的来说，这些病毒是全球卫生的最大负担之一，因为它们广泛流行，并在人类和动物宿主中造成严重的发病率和死亡率。蚊媒病原体的具体例子包括寨卡病毒(ZIKV)、西尼罗河病毒(WNV)、1-4型登革病毒(DENV 1-4)、日本脑炎病毒(JEV)、黄热病病毒(YFV)、基孔肯雅热病毒(CHIKV)和裂谷热病毒(RVFV)。虫媒病毒与脊椎动物宿主的免疫途径之间的相互作用已被广泛综述。在这篇综述中，我们重点介绍了蚊子体内存在的抗病毒免疫途径。我们还讨论了蚊媒病毒可能对抗疾病媒介中的抗病毒途径的机制。最后，我们阐述了蚊媒病毒可能与其无脊椎动物媒介宿主进行进化军备竞赛的可能性，以及这对理解蚊媒病毒传播的可能含义。
More than 100 pathogens, spanning multiple virus families, broadly termed “arthropod-borne viruses (arboviruses)” have been associated with human and/or animal diseases. These viruses persist in nature through transmission cycles that involve alternating replication in susceptible vertebrate and invertebrate hosts. Collectively, these viruses are among the greatest burdens to global health, due to their widespread prevalence, and the severe morbidity and mortality they cause in human and animal hosts. Specific examples of mosquito-borne pathogens include Zika virus (ZIKV), West Nile virus (WNV), dengue virus serotypes 1-4 (DENV 1-4), Japanese encephalitis virus (JEV), yellow fever virus (YFV), chikungunya (CHIKV), and Rift Valley fever virus (RVFV). Interactions between arboviruses and the immune pathways of vertebrate hosts have been extensively reviewed. In this review we focus on the antiviral immune pathways present in mosquitoes. We also discuss mechanisms by which mosquito-borne viruses may antagonize antiviral pathways in disease vectors. Finally, we elaborate on the possibility that mosquito – borne viruses may be engaged in an evolutionary arms race with their invertebrate vector hosts, and the possible implications of this for understanding the transmission of mosquito-borne viruses.
登录
查看更多内容
影响因子：
3.7
作者：
Costa A;Jan E;Sarnow P;Schneider D
通讯作者：
Schneider D
影响因子：
2.6
作者：
Campbell CL;Harrison T;Hess AM;Ebel GD
通讯作者：
Ebel GD
影响因子：
4.2
作者：
Campbell CL;Keene KM;Brackney DE;Olson KE;Blair CD;Wilusz J;Foy BD
通讯作者：
Foy BD
影响因子：
23.8
作者：
CHAMBERLAIN, R;SUDIA, WD
通讯作者：
SUDIA, WD
影响因子：
10.5
作者：
Azevedo, Jacinthe;Garcia, Damien;Voinnet, Olivier
通讯作者：
Voinnet, Olivier