Role of endothelial cells in graft-versus-host disease.
Role of endothelial cells in graft-versus-host disease.
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DOI：
10.3389/fimmu.2022.1033490
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发表时间：
2022
影响因子：
7.3
通讯作者：
Ranganathan, Parvathi
中科院分区：
文献类型：
--
作者：
Neidemire-Colley, Lotus;Robert, Jeremy;Ackaoui, Antoine;Dorrance, Adrienne. M. M.;Guimond, Martin;Ranganathan, Parvathi
迄今为止，对标准化疗无反应的高风险或难治性血液恶性肿瘤的唯一治疗方法是同种异体造血移植（allo-HCT）。急性移植物抗宿主病 (GVHD) 是一种供体 T 细胞介导的免疫性疾病，通常是致命的，也是异基因 HCT 后患者非复发死亡 (NRM) 的主要原因。急性 GVHD 的发病机制涉及供体 T 细胞识别次要和/或主要 HLA 不匹配的宿主抗原，随后由于炎性细胞因子分泌和直接细胞毒性作用的结合而扩张、迁移，最后造成终末器官损伤。内皮是一层薄薄的内皮细胞 (EC)，排列在血管的最内层，是血管稳态和炎症反应的关键调节因子。内皮细胞被多种炎症介质激活，包括细菌产物、死亡/凋亡细胞释放的内容物和细胞因子，并通过分泌细胞因子/趋化因子做出反应，促进先天性和适应性免疫细胞募集到炎症部位。内皮细胞也可能在移植前以及同种异体反应性供体 T 细胞受到损伤。长时间的 EC 激活会导致功能障碍，从而导致多种移植后并发症，包括但不限于静脉闭塞性疾病 (VOD)、移植相关血栓性微血管病 (TA-TMA) 和特发性肺炎综合征。在这篇小综述中，我们总结了内皮细胞的生物学、调节 EC 激活的因素以及 EC 在炎症和 GVHD 发病机制中的作用。
To date, the only curative treatment for high-risk or refractory hematologic malignancies non-responsive to standard chemotherapy is allogeneic hematopoietic transplantation (allo-HCT). Acute graft-versus-host disease (GVHD) is a donor T cell-mediated immunological disorder that is frequently fatal and the leading cause of non-relapse mortality (NRM) in patients post allo-HCT. The pathogenesis of acute GVHD involves recognition of minor and/or major HLA mismatched host antigens by donor T cells followed by expansion, migration and finally end-organ damage due to combination of inflammatory cytokine secretion and direct cytotoxic effects. The endothelium is a thin layer of endothelial cells (EC) that line the innermost portion of the blood vessels and a key regulator in vascular homeostasis and inflammatory responses. Endothelial cells are activated by a wide range of inflammatory mediators including bacterial products, contents released from dying/apoptotic cells and cytokines and respond by secreting cytokines/chemokines that facilitate the recruitment of innate and adaptive immune cells to the site of inflammation. Endothelial cells can also be damaged prior to transplant as well as by alloreactive donor T cells. Prolonged EC activation results in dysfunction that plays a role in multiple post-transplant complications including but not limited to veno-occlusive disease (VOD), transplant associated thrombotic microangiopathy (TA-TMA), and idiopathic pneumonia syndrome. In this mini review, we summarize the biology of endothelial cells, factors regulating EC activation and the role of ECs in inflammation and GVHD pathogenesis.
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影响因子：
7.5
作者：
Gergoudis, Stephanie C.;DeFilipp, Zachariah;Levine, John E.
通讯作者：
Levine, John E.
影响因子：
10.1
作者：
Cordes S;Mokhtari Z;Bartosova M;Mertlitz S;Riesner K;Shi Y;Mengwasser J;Kalupa M;McGeary A;Schleifenbaum J;Schrezenmeier J;Bullinger L;Diaz-Ricart M;Palomo M;Carrreras E;Beutel G;Schmitt CP;Beilhack A;Penack O
通讯作者：
Penack O
影响因子：
7.3
作者：
Ali AJ;Abuelela AF;Merzaban JS
通讯作者：
Merzaban JS
影响因子：
4.3
作者：
Cutler, Corey;Kim, Haesook T.;Antin, Joseph H.
通讯作者：
Antin, Joseph H.
影响因子：
4.3
作者：
Dietrich, Sascha;Falk, Christine S.;Luft, Thomas
通讯作者：
Luft, Thomas