Phorbol ester inhibition of chicken intestinal brush-border sodium-proton exchange.
Phorbol ester inhibition of chicken intestinal brush-border sodium-proton exchange.
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佛波酯抑制鸡肠道刷状缘钠质子交换。
DOI：
10.1152/ajpcell.1991.260.6.c1264
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Rao,MC
中科院分区：
文献类型：
--
作者：
Chang,EB;Musch,MW;Drabik-Arvans,D;Rao,MC
Phorbol esters, specific activators of protein kinase C, inhibit amiloride-sensitive Na uptake from the mucosal medium in intact intestinal mucosa as well as in isolated chicken villus enterocytes. In isolated cells, maximal inhibition is observed at 60 s, and influx returns to control values within 15 min. This effect can be measured either as initial 22Na influx rates or by following changes in intracellular pH using the pH-sensitive fluorescent dye 5,6-carboxyfluorescein. The effects of amiloride and phorbol esters were not additive, suggesting inhibition of a common transport system, i.e., Na-H exchange. In brush-border membrane vesicles (BBMV) made from villus enterocytes, amiloride-sensitive Na-H exchange activity was significantly inhibited in phorbol ester-treated cells. The degree of inhibition of 22Na uptake by BBMV had the same time course and dose-effect relationship as phorbol ester-inhibited cellular Na uptake. Similarly, the time course of protein kinase C translocation from cytosol to particulate or brush-border membrane fractions correlated with Na uptake measurements made in whole cells and BBMV. These results suggest that protein kinase C activation in chicken villus enterocytes inhibits brush-border membrane Na-H exchange activity.
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佛波酯刺激鸡回肠分泌：花生四烯酸代谢的作用。
影响因子：
29.4
作者：
Musch,MW;Nahkla,AM;Chang,EB
通讯作者：
Chang,EB
从牛气管上皮中分离运输质膜囊泡。
DOI：
10.1016/0005-2736(83)90024-x
发表时间：
1983
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Langridge-Smith,JE;Field,M;Dubinsky,WP
通讯作者：
Dubinsky,WP
培养成纤维细胞中 Na /H 交换的激活：佛波酯、Ca2 离子载体和生长因子之间的协同和拮抗作用。
DOI：
10.1073/pnas.82.23.8053
发表时间：
1985
影响因子：
11.1
作者：
Vicentini,LM;Villereal,ML
通讯作者：
Villereal,ML
犬回肠氯化物吸收：碳酸酐酶抑制剂对运输的影响。
DOI：
10.1152/ajplegacy.1964.207.5.998
发表时间：
1964
期刊：
The American journal of physiology
影响因子：
--
作者：
V. R. Kinney;C. F. Code
通讯作者：
C. F. Code
芳香氨基酸与人类胃促分泌剂的相互作用。
影响因子：
29.4
作者：
H. Lenz;T. Struck;H. Greten
通讯作者：
H. Greten