Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans.
Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans.
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DOI:
10.1126/science.1198719
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发表时间:
2011-05-20
期刊:
影响因子:
--
通讯作者:
Gordon JI
中科院分区:
文献类型:
--
作者:
Muegge BD;Kuczynski J;Knights D;Clemente JC;González A;Fontana L;Henrissat B;Knight R;Gordon JI
Co-evolution of mammals and their gut microbiota has profoundly effected their radiation into myriad habitats. We used shotgun sequencing of microbial community DNA and targeted sequencing of bacterial 16S rRNA genes to understand how microbial communities adapt to extremes of diets, sampling fecal DNAs from 33 mammalian species and 18 humans who kept detailed diet records. We found that microbiota adaptation to diet is reproducible across different mammalian lineages. Functional repertoires of microbiome genes, such as those encoding carbohydrate-active enzymes and proteases, can be predicted from bacterial species assemblages. These results illustrate the value of characterizing vertebrate gut microbiomes to fully understand host evolutionary histories at a supra-organismal level.
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