Prefrontal cortex executive processes affected by stress in health and disease.
Prefrontal cortex executive processes affected by stress in health and disease.
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DOI：
10.1016/j.pnpbp.2017.07.004
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发表时间：
2018-07-13
影响因子：
5.6
通讯作者：
Morilak DA
中科院分区：
文献类型：
--
作者：
Girotti M;Adler SM;Bulin SE;Fucich EA;Paredes D;Morilak DA
前额皮质执行功能包括目标导向行为和适应不断变化的环境所必需的许多认知能力。执行功能障碍会导致适应不良行为，并且是精神病理学的症状，可能会因压力而引发或加剧。在这篇综述中，我们调查了有关压力对执行功能影响的研究，特别关注工作记忆、注意力、反应抑制和认知灵活性。然后，我们考虑这些认知能力背后的神经化学途径，以及已知的压力如何改变它们。最后，我们回顾了探索可以改善执行功能缺陷的潜在药理学和非药理学方法的工作。临床前和临床文献均表明，慢性压力会对执行功能产生负面影响。尽管执行功能背后的一些电路和神经化学过程已经被表征，但关于压力如何影响这些过程仍然有很多未知。为了在改善执行功能障碍的干预措施方面取得进展，需要针对这个问题进行更多的工作。
Prefrontal cortical executive functions comprise a number of cognitive capabilities necessary for goal directed behavior and adaptation to a changing environment. Executive dysfunction that leads to maladaptive behavior and is a symptom of psychiatric pathology can be instigated or exacerbated by stress. In this review we survey research addressing the impact of stress on executive function, with specific focus on working memory, attention, response inhibition, and cognitive flexibility. We then consider the neurochemical pathways underlying these cognitive capabilities and, where known, how stress alters them. Finally, we review work exploring potential pharmacological and non-pharmacological approaches that can ameliorate deficits in executive function. Both preclinical and clinical literature indicates that chronic stress negatively affects executive function. Although some of the circuitry and neurochemical processes underlying executive function have been characterized, a great deal is still unknown regarding how stress affects these processes. Additional work focusing on this question is needed in order to make progress on developing interventions that ameliorate executive dysfunction.
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影响因子：
64.8
作者：
Autry, Anita E.;Adachi, Megunai;Nosyreva, Elena;Na, Elisa S.;Los, Maarten F.;Cheng, Peng-fei;Kavalali, Ege T.;Monteggia, Lisa M.
通讯作者：
Monteggia, Lisa M.
影响因子：
3.4
作者：
ANGRIST, B;ROTROSEN, J;GERSHON, S
通讯作者：
GERSHON, S
影响因子：
3.4
作者：
Alsiö J;Nilsson SR;Gastambide F;Wang RA;Dam SA;Mar AC;Tricklebank M;Robbins TW
通讯作者：
Robbins TW
DOI：
10.1016/j.cortex.2012.05.022
发表时间：
2013-05
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Barbey AK;Koenigs M;Grafman J
通讯作者：
Grafman J
影响因子：
10.6
作者：
Aron, AR;Poldrack, RA
通讯作者：
Poldrack, RA