Loss of pattern separation performance in schizophrenia suggests dentate gyrus dysfunction.
Loss of pattern separation performance in schizophrenia suggests dentate gyrus dysfunction.
复制标题
DOI：
10.1016/j.schres.2014.05.006
复制
发表时间：
2014-10
影响因子：
4.5
通讯作者：
Tamminga CA
中科院分区：
文献类型：
--
作者：
Das T;Ivleva EI;Wagner AD;Stark CE;Tamminga CA
Motivated by evidence that the dentate gyrus differentially mediates the pattern separation (PS) component of declarative memory function and that dentate gyrus harbors molecular and cellular pathology in schizophrenia, we examined whether PS performance is altered in volunteers with schizophrenia (SZV) relative to healthy volunteers (HV). In groups of well-characterized SZV (n=14) and HV (n=15), we contrasted performance on the Behavioral Pattern Separation (BPS) Task, acquiring two outcome measures, a PS parameter and a Recognition Memory (RM) parameter, as well as specific recognition data by stimulus type. The SZVs showed a significant decrement in PS performance relative to HV (mean±SE, SZV: 3.1%±4.8; HV: 17.1%±4.7; p=0.039, d=0.86); whereas SZV and HV did not significantly differ in RM performance (SZV: 50.1%±4.8; HV: 59.3%±4.7; p=0.350, d=0.36). Moreover, the SZVs showed a selective defect in correctly identifying similar lure items (SZV: 24.0%±4.1; HV: 41.2%±4.1; p<0.05), but demonstrated no impairment in identifying targets and novel foils. These data suggest that dentate gyrus is dysfunctional in schizophrenia, a feature that could contribute to declarative memory impairment in the disorder and possibly to psychosis, a conclusion consistent with the considerable molecular pathology in dentate gyrus in schizophrenia.
登录
查看更多内容
影响因子：
3
作者：
Rolls ET
通讯作者：
Rolls ET
影响因子：
3.7
作者：
BAILEY, BJR
通讯作者：
BAILEY, BJR
影响因子：
3.5
作者：
OREILLY, RC;MCCLELLAND, JL
通讯作者：
MCCLELLAND, JL
影响因子：
5.3
作者：
LaRocque, Karen F.;Smith, Mary E.;Wagner, Anthony D.
通讯作者：
Wagner, Anthony D.
影响因子：
2
作者：
Stark, Shauna M.;Yassa, Michael A.;Stark, Craig E. L.
通讯作者：
Stark, Craig E. L.