Identification of Gut Bacteria such as Lactobacillus johnsonii that Disseminate to Systemic Tissues of Wild Type and MyD88-/- Mice.
Identification of Gut Bacteria such as Lactobacillus johnsonii that Disseminate to Systemic Tissues of Wild Type and MyD88-/- Mice.
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DOI：
10.1080/19490976.2021.2007743
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发表时间：
2022-01
期刊：
影响因子：
12.2
通讯作者：
Nally K
中科院分区：
文献类型：
--
作者：
Udayan S;Stamou P;Crispie F;Hickey A;Floyd AN;Hsieh CS;Cotter PD;O'Sullivan O;Melgar S;O'Toole PW;Newberry RD;Rossini V;Nally K
In healthy hosts the gut microbiota is restricted to gut tissues by several barriers some of which require MyD88-dependent innate immune sensor pathways. Nevertheless, some gut taxa have been reported to disseminate to systemic tissues. However, the extent to which this normally occurs during homeostasis in healthy organisms is still unknown. In this study, we recovered viable gut bacteria from systemic tissues of healthy wild type (WT) and MyD88−/− mice. Shotgun metagenomic-sequencing revealed a marked increase in the relative abundance of L. johnsonii in intestinal tissues of MyD88−/− mice compared to WT mice. Lactobacillus johnsonii was detected most frequently from multiple systemic tissues and at higher levels in MyD88−/− mice compared to WT mice. Viable L. johnsonii strains were recovered from different cell types sorted from intestinal and systemic tissues of WT and MyD88−/− mice. L. johnsonii could persist in dendritic cells and may represent murine immunomodulatory endosymbionts.
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影响因子：
32.4
作者：
Fung TC;Bessman NJ;Hepworth MR;Kumar N;Shibata N;Kobuley D;Wang K;Ziegler CGK;Goc J;Shima T;Umesaki Y;Sartor RB;Sullivan KV;Lawley TD;Kunisawa J;Kiyono H;Sonnenberg GF
通讯作者：
Sonnenberg GF
影响因子：
24.5
作者：
Knoop KA;McDonald KG;Kulkarni DH;Newberry RD
通讯作者：
Newberry RD
影响因子：
9.8
作者：
Stecher, Barbel;Robbiani, Riccardo;Walker, Alan W;Westendorf, Astrid M;Barthel, Manja;Kremer, Marcus;Chaffron, Samuel;Macpherson, Andrew J;Buer, Jan;Parkhill, Julian;Dougan, Gordon;von Mering, Christian;Hardt, Wolf-Dietrich
通讯作者：
Hardt, Wolf-Dietrich
影响因子：
5.2
作者：
Adegoke AA;Stenström TA;Okoh AI
通讯作者：
Okoh AI
影响因子：
17.1
作者：
Aagaard K;Ma J;Antony KM;Ganu R;Petrosino J;Versalovic J
通讯作者：
Versalovic J