Pathobiological implications of mucin (MUC) expression in the outcome of small bowel cancer.
Pathobiological implications of mucin (MUC) expression in the outcome of small bowel cancer.
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DOI：
10.1371/journal.pone.0086111
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yonezawa S
中科院分区：
文献类型：
--
作者：
Shibahara H;Higashi M;Koriyama C;Yokoyama S;Kitazono I;Kurumiya Y;Narita M;Kuze S;Kyokane T;Mita S;Arai T;Kato T;Yuasa N;Yamaguchi R;Kubota H;Suzuki H;Baba S;Rousseau K;Batra SK;Yonezawa S
黏液蛋白与各种癌症患者的生存有关，但黏液蛋白在小肠癌（SBC）中的作用尚未有研究。本研究通过免疫组化检测60例SBC患者MUC1、MUC2、MUC3、MUC4、MUC5AC、MUC6、MUC16在癌组织和正常组织中的表达谱，探讨了mucin表达与临床病理因素的关系。与正常上皮相比，SBC病变中MUC1、MUC5AC、MUC16表达增加，且MUC1[肿瘤位置（p = 0.019）、深度（p = 0.017）、可治愈性（p = 0.007）]、MUC5AC[肿瘤位置（p = 0.063）、淋巴结转移（p = 0.059）]、MUC16[静脉浸润（p = 0.016）、可治愈性（p = 0.016）]的表达与临床病理因素有关。对58例患者的生存资料进行分析，除MUC1 （p = 0.042）、MUC5AC （p = 0.007）、MUC16 （p<0.001）表达外，与预后不良相关的5个因素为：低分化或神经内分泌组织学类型（p<0.001）、淋巴结转移（p<0.001）、淋巴浸润（p = 0.026）、静脉浸润（p<0.001）和治愈性切除（p<0.001）。在随后以治愈率为变量的多因素分析中，淋巴结转移、静脉浸润、MUC5AC和/或MUC16表达与预后显著相关。对治愈病例（n = 45）的多因素分析显示，在调整静脉侵入的影响后，MUC5AC和/或MUC16表达的SBC具有显著独立的高危险风险（风险比：5.6,95%可信区间：1.8-17）。总之，该研究表明muc5ac阳性和/或muc16阳性状态可作为SBC患者预后不良的预测指标。
Mucins have been associated with survival in various cancer patients, but there have been no studies of mucins in small bowel carcinoma (SBC). In this study, we investigated the relationships between mucin expression and clinicopathologic factors in 60 SBC cases, in which expression profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6 and MUC16 in cancer and normal tissues were examined by immunohistochemistry. MUC1, MUC5AC and MUC16 expression was increased in SBC lesions compared to the normal epithelium, and expression of these mucins was related to clinicopathologic factors, as follows: MUC1 [tumor location (p = 0.019), depth (p = 0.017) and curability (p = 0.007)], MUC5AC [tumor location (p = 0.063) and lymph node metastasis (p = 0.059)], and MUC16 [venous invasion (p = 0.016) and curability (p = 0.016)]. Analysis of 58 cases with survival data revealed five factors associated with a poor prognosis: poorly-differentiated or neuroendocrine histological type (p<0.001), lymph node metastasis (p<0.001), lymphatic invasion (p = 0.026), venous invasion (p<0.001) and curative resection (p<0.001), in addition to expression of MUC1 (p = 0.042), MUC5AC (p = 0.007) and MUC16 (p<0.001). In subsequent multivariate analysis with curability as the covariate, lymph node metastasis, venous invasion, and MUC5AC and/or MUC16 expression were significantly related to the prognosis. Multivariate analysis in curative cases (n = 45) showed that SBC with MUC5AC and/or MUC16 expression had a significantly independent high hazard risk after adjusting for the effects of venous invasion (hazard ratio: 5.6, 95% confidence interval: 1.8–17). In conclusion, the study shows that a MUC5AC-positive and/or MUC16-positive status is useful as a predictor of a poor outcome in patients with SBC.
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3.2
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