Ischemic diabetic retinopathy may protect against nuclear sclerotic cataract.
Ischemic diabetic retinopathy may protect against nuclear sclerotic cataract.
复制标题
DOI：
10.1016/j.ajo.2010.05.013
复制
发表时间：
2010-10
影响因子：
4.2
通讯作者：
Beebe, David C.
中科院分区：
文献类型：
--
作者：
Holekamp, Nancy M.;Bai, Fang;Shui, Ying-Bo;Almony, Arghavan;Beebe, David C.
目的：探讨糖尿病对玻璃体切除术后6个月和12个月的核硬化性白内障是否具有保护作用。前瞻性干预队列研究因各种视网膜状况接受玻璃体切除手术的有晶状体糖尿病患者和非糖尿病患者在基线和玻璃体切除手术后6个月和12个月对手术眼和对侧眼进行Scheimpflg晶状体摄影。在纳入分析的52只眼中，23只眼来自糖尿病患者，其中14只眼接受了缺血性视网膜病变的手术。在基线时，与非缺血性糖尿病和非糖尿病眼相比，缺血性糖尿病视网膜病变眼的核硬化性白内障较少。接受玻璃体切除手术的眼睛(p=0.0001)和对侧眼(p=0.003)也是如此。玻璃体切除手术后，非缺血型糖尿病眼和非糖尿病眼发生核硬化性白内障的比例相同。有缺血性视网膜病变的糖尿病眼没有明显的核混浊进展，因此，玻璃体切除术后6个月(p<；1×10−6)和12个月(p<；0.001)的核性白内障明显少于非糖尿病或非缺血性糖尿病眼。正常化到基线不透明度，并根据年龄和其他并发症进行调整，并没有改变这一结果。缺血性糖尿病视网膜病变，而不仅仅是全身性糖尿病，在基线和玻璃体手术后对核硬化性白内障具有保护作用。这些发现与增加接触氧气是核性白内障形成的原因的假设是一致的。
To determine whether diabetes mellitus is protective for nuclear sclerotic cataract at baseline and 6 and 12 months after vitrectomy surgery. Prospective interventional cohort study Phakic diabetic and non-diabetic patients undergoing vitrectomy surgery for a variety of retinal conditions underwent Scheimpflug lens photography in the operated and fellow eye at baseline and 6 and 12 months following vitrectomy surgery. Of 52 eyes included in the analysis, 23 eyes were from diabetic patients, 14 of which had surgery for ischemic retinopathy. At baseline, eyes with ischemic diabetic retinopathy had less nuclear sclerotic cataract than non-ischemic diabetic and non-diabetic eyes. This was true for eyes undergoing vitrectomy surgery (p=0.0001) and for fellow eyes (p=0.003). After vitrectomy surgery, non-ischemic diabetic eyes and non-diabetic eyes developed nuclear sclerotic cataract at the same rate. Diabetic eyes with ischemic retinopathy showed no significant progression of nuclear opacification and, therefore, had significantly less post-vitrectomy nuclear cataract at 6 months (p<1×10−6) and at 12 months (p<0.001) than non-diabetic or non-ischemic diabetic eyes. Normalizing to baseline opacity and adjusting for age and other co-morbidities did not alter this result. Ischemic diabetic retinopathy, not just systemic diabetes mellitus, protected against nuclear sclerotic cataract at baseline and following vitrectomy surgery. These findings are consistent with the hypothesis that increased exposure to oxygen is responsible for nuclear cataract formation.
登录
查看更多内容
影响因子：
4.2
作者：
DEBUSTROS, S;THOMPSON, JT;GLASER, BM
通讯作者：
GLASER, BM
影响因子：
--
作者：
Shui, Ying-Bo;Holekamp, Nancy M.;Kramer, Benjamin C.;Crowley, Jan R.;Wilkins, Mark A.;Chu, Fred;Malone, Paula E.;Mangers, Shayna J.;Hou, Joshua H.;Siegfried, Carla J.;Beebe, David C.
通讯作者：
Beebe, David C.
影响因子：
1.8
作者：
COOK, CA;KORETZ, JF;KAUFMAN, PL
通讯作者：
KAUFMAN, PL
影响因子：
1.8
作者：
West, Sheila
通讯作者：
West, Sheila
影响因子：
4.2
作者：
THOMPSON, JT;GLASER, BM;MURPHY, RP
通讯作者：
MURPHY, RP