Impairment in shifting attention in autistic and cerebellar patients.

Impairment in shifting attention in autistic and cerebellar patients.
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自闭症和小脑患者注意力转移受损。

DOI:
10.1037//0735-7044.108.5.848
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发表时间:
1994
影响因子:
1.9
通讯作者:
Lau,L
Lau,L
中科院分区:
医学4区
文献类型:
--
作者:
Courchesne,E;Townsend,J;Akshoomoff,NA;Saitoh,O;Yeung-Courchesne,R;Lincoln,AJ;James,HE;Haas,RH;Schreibman,L;Lau,L

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自闭症患者小脑蚓部和半球早期发育不良的磁共振成像(MRI)和尸检证据提出了一个问题,即小脑发育不良如何导致自闭症的认知和社会缺陷。与18名正常对照组相比,8名自闭症患者(平均年龄13.9岁)和6名后天性小脑病变患者(平均年龄8.6岁)在一项要求在听觉和视觉刺激之间快速准确转移注意力的任务中受到类似的损害。神经生理学和行为学证据排除了运动功能障碍是这种缺陷的原因。这些发现与自闭症中小脑发育不良可能导致无法执行快速注意力转移的提议一致,这反过来又会破坏社会和认知发展。研究结果支持的建议,人类小脑参与协调的快速注意力转移的方式类似于其在协调运动的作用。(PsycInfo数据库记录(c)2016阿帕,保留所有权利)
Magnetic resonance imaging (MRI) and autopsy evidence of early maldevelopment of cerebellar vermis and hemispheres in autism raises the question of how cerebellar maldevelopment contributes to the cognitive and social deficits characteristic of autism. Compared with 18 normal controls, 8 autistic patients (mean age 13.9 yrs) and 6 patients (mean age 8.6 yrs) with acquired cerebellar lesions were similarly impaired in a task requiring rapid and accurate shifts of attention between auditory and visual stimuli. Neurophysiologic and behavioral evidence rules out motor dysfunction as the cause of this deficit. These findings are consistent with the proposal that in autism cerebellar maldevelopment may contribute to an inability to execute rapid attention shifts, which in turn undermines social and cognitive development. Findings support the proposal that the human cerebellum is involved in the coordination of rapid attention shifts in a fashion analogous to its role in the coordination of movement.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
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