Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk.
Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk.
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DOI：
10.3390/nano7100307
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发表时间：
2017-10-06
期刊：
影响因子：
--
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Kornberg TG;Stueckle TA;Antonini JA;Rojanasakul Y;Castranova V;Yang Y;Wang L
细小/微米大小的氧化铁颗粒偶然从许多工业过程中释放出来，包括铁矿石开采、钢铁加工、焊接和黄铁矿生产。一些研究表明，职业性接触这些颗粒会增加呼吸道不良后果的风险，而其他研究表明，氧化铁在生物学上是良性的。氧化铁纳米颗粒（IONPs）直径小于100纳米，近年来作为新型药物输送系统的组成部分、独特的成像方案、环境催化剂以及热塑性塑料的掺入物的使用激增。然而，与职业暴露于离子内酯相关的不良后果仍然相对未知。相关体内研究表明，暴露于IONPs的肺部可诱导炎症、肺纤维化、遗传毒性和肺外效应。这与利用相关剂量、细胞类型和有意义终点的体外研究密切相关。这些不良后果大多归因于氧化应激的增加，很可能是由颗粒内化、溶解、释放游离铁离子和破坏铁稳态引起的。然而，由于IONPs的总体毒性特征尚不清楚，因此很难制定足以保护处于危险中的工人的安全暴露限值建议。这篇综述文章将重点关注基于人类、动物和细胞培养的研究支持的离子接触后的已知风险，离子毒性评估固有的潜在挑战，以及这些挑战如何导致离子毒性特征不明确。
Fine/micron-sized iron oxide particulates are incidentally released from a number of industrial processes, including iron ore mining, steel processing, welding, and pyrite production. Some research suggests that occupational exposure to these particulates is linked to an increased risk of adverse respiratory outcomes, whereas other studies suggest that iron oxide is biologically benign. Iron oxide nanoparticles (IONPs), which are less than 100 nm in diameter, have recently surged in use as components of novel drug delivery systems, unique imaging protocols, as environmental catalysts, and for incorporation into thermoplastics. However, the adverse outcomes associated with occupational exposure to IONPs remain relatively unknown. Relevant in vivo studies suggest that pulmonary exposure to IONPs may induce inflammation, pulmonary fibrosis, genotoxicity, and extra-pulmonary effects. This correlates well with in vitro studies that utilize relevant dose, cell type(s), and meaningful end points. A majority of these adverse outcomes are attributed to increased oxidative stress, most likely caused by particle internalization, dissolution, release of free iron ions, and disruption of iron homeostasis. However, because the overall toxicity profile of IONPs is not well understood, it is difficult to set safe exposure limit recommendations that would be adequate for the protection of at-risk workers. This review article will focus on known risks following IONPs exposure supported by human, animal, and cell culture-based studies, the potential challenges intrinsic to IONPs toxicity assessment, and how these may contribute to the poorly characterized IONPs toxicity profile.
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影响因子：
10.4
作者：
Beaver LM;Stemmy EJ;Schwartz AM;Damsker JM;Constant SL;Ceryak SM;Patierno SR
通讯作者：
Patierno SR
氧化铁纳米颗粒的双重酶样活性及其对减少细胞毒性的意义
影响因子：
17.1
作者：
Chen, Zhongwen;Yin, Jun-Jie;Gu, Ning
通讯作者：
Gu, Ning
DOI：
10.1016/j.msec.2017.04.030
发表时间：
2017-09-01
影响因子：
7.9
作者：
Bekaroglu, Maide Gokce;Isci, Yavuz;Isci, Sevim
通讯作者：
Isci, Sevim
影响因子：
5.8
作者：
Dwivedi, Sourabh;Siddiqui, Maqsood A.;Al-Khedhairy, Abdulaziz A.
通讯作者：
Al-Khedhairy, Abdulaziz A.
影响因子：
9.9
作者：
Guldris, Noelia;Argibay, Barbara;Rivas, Jose
通讯作者：
Rivas, Jose