Gender difference in the association between cough severity and quality of life among patients with postinfectious cough.
Gender difference in the association between cough severity and quality of life among patients with postinfectious cough.
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感染后咳嗽患者咳嗽严重程度与生活质量关系的性别差异
DOI：
10.1186/s12955-021-01680-5
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发表时间：
2021-01-26
影响因子：
3.6
通讯作者：
Jiang H
中科院分区：
文献类型：
--
作者：
Liu W;Wu Q;Mao B;Jiang H
尽管咳嗽的严重程度与生活质量密切相关，但咳嗽对生活质量的影响是否存在性别差异尚未得到研究。本研究的主要目的是调查感染后咳嗽患者的咳嗽严重程度与生活质量之间的关系是否受性别的影响。方法采用多点随机对照试验，对180例感染后咳嗽患者进行二次分析。收集基线人口学资料、临床特征和咳嗽特有生活质量问卷(CQLQ)评分。结果在非校正分析中，男女间CQLQ总分差异无统计学意义(P= 0.077)。在调整了年龄、咳嗽持续时间、咳嗽严重程度和临床中心后，女性的CQLQ总分比男性高出2.20分(95%可信区间为0.11-4.30；P= 0.039)。在调整了年龄、咳嗽持续时间和研究中心后，性别显著改变了咳嗽严重程度与CQLQ总分之间的关联(系数1.80，95%可信区间0.29~3.30；P= 0.020)。咳嗽严重程度每增加1分，女性的生活质量总分增加2.55分(95%可信区间：1.16~3.95)，而男性增加1.26分(95%可信区间：0.20~2.31)(P= 0.020)。结论女性的生活质量可能比男性差，而且随着咳嗽症状的加重，女性的生活质量受损程度可能更大。在咳嗽和咳嗽相关生活质量的临床设置和研究中应考虑性别差异。试验注册：中国临床试验注册中心，ChiCTRTRC12002297。2012年6月19日注册，http://www.chictr.org.cn/abouten.aspx。
BackgroundDespite close link exists between cough severity and quality of life (QoL), whether gender difference is implied in the effect of cough on QoL has not been studied yet. This study primarily aims to investigate whether the association between cough severity and QoL is modified by gender in patients with postinfectious cough.MethodsSecondary analyses were performed in 180 participants with postinfectious cough in a multisite randomized controlled trial. Baseline demographics, clinical characteristics and score of cough specific quality of life questionnaire (CQLQ) were collected. Linear regression analyses were conducted to examine gender difference in CQLQ score and the association between cough severity and CQLQ score.ResultsDifference between women and men was not significant in CQLQ total score in the unadjusted analysis (P= 0.077). Women had a 2.20-point higher CQLQ total score than men (95% confidence interval (CI) 0.11–4.30;P= 0.039), after adjusting for age, cough duration, cough severity, and clinical center. Gender significantly modified the association between cough severity and CQLQ total score (coefficient 1.80, 95% CI 0.29–3.30;P= 0.020), after adjusting for age, cough duration, and study center. An increase of 1-point in cough severity was associated with a 2.55-point (95% CI 1.16–3.95) increase in CQLQ total score in women versus a 1.26-point (95% CI 0.20–2.31) increase in men (P= 0.020).ConclusionsFemale sex may be associated with worse QoL than men, and women’s QoL may be more significantly impaired as cough symptom deteriorates. Gender difference should be taken into account in the clinical settings and research of cough and cough related QoL.Trial registration: Chinese Clinical Trial Registry, ChiCTRTRC12002297. Registered 19 June 2012, http://www.chictr.org.cn/abouten.aspx .
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作者：
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Mansson, Jorgen;Nilsson, Gunnar;Bjorkelund, Cecilia
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