Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions.
Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions.
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DOI：
10.1038/s41598-021-93775-8
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发表时间：
2021-07-15
影响因子：
4.6
通讯作者：
Eugenin EA
中科院分区：
文献类型：
--
作者：
Valdebenito S;Malik S;Luu R;Loudig O;Mitchell M;Okafo G;Bhat K;Prideaux B;Eugenin EA
细胞间通讯对于多细胞系统的发育和正常功能至关重要。我们和其他人证明了隧道纳米管（TNT）在几种病理条件下增殖，如艾滋病毒，癌症和神经退行性疾病。然而，TNT的性质，功能和对癌症发病机制的贡献知之甚少。我们的分析表明，胶质母细胞瘤（GBM）细胞和周围的非肿瘤星形胶质细胞之间的TNT结构诱导转移肿瘤来源的线粒体。TNT介导的线粒体转移导致非肿瘤星形胶质细胞适应肿瘤样代谢和缺氧条件。总之，TNT是一种有效的细胞间通讯系统，癌细胞使用它来使微环境适应肿瘤的侵袭性。
Cell-to-cell communication is essential for the development and proper function of multicellular systems. We and others demonstrated that tunneling nanotubes (TNT) proliferate in several pathological conditions such as HIV, cancer, and neurodegenerative diseases. However, the nature, function, and contribution of TNT to cancer pathogenesis are poorly understood. Our analyses demonstrate that TNT structures are induced between glioblastoma (GBM) cells and surrounding non-tumor astrocytes to transfer tumor-derived mitochondria. The mitochondrial transfer mediated by TNT resulted in the adaptation of non-tumor astrocytes to tumor-like metabolism and hypoxia conditions. In conclusion, TNT are an efficient cell-to-cell communication system used by cancer cells to adapt the microenvironment to the invasive nature of the tumor.
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