Beyond glucose: alternative sources of energy in glioblastoma.
Beyond glucose: alternative sources of energy in glioblastoma.
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DOI：
10.7150/thno.53506
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发表时间：
2021
期刊：
影响因子：
12.4
通讯作者：
Velpula KK
中科院分区：
文献类型：
--
作者：
Caniglia JL;Jalasutram A;Asuthkar S;Sahagun J;Park S;Ravindra A;Tsung AJ;Guda MR;Velpula KK
多形性胶质母细胞瘤（GBM）是成人最常见的恶性脑肿瘤。它也是最致命的原发性脑肿瘤，中位生存期仅为15个月。这通常是尽管积极的治疗，包括手术切除，放射治疗和化疗。基于肿瘤的不良结局和患病率，对创新疗法的需求仍然是临床医生和研究人员的紧迫问题。在靶向代谢的治疗方面，瓦尔堡效应的流行导致了对靶向葡萄糖代谢以阻止肿瘤进展的关注。虽然葡萄糖是GBM中生长底物的主要来源，但在GBM中利用了许多独特的代谢途径来满足对复制和进展的增加的需求。在这篇综述中，我们的目的是探讨如何从脂肪酸氧化，尿素循环，谷氨酸-谷氨酰胺循环，和一碳代谢的代谢产物被分流到能源生产途径，以满足高能量需求的GBM。我们还将探索自噬过程如何提供营养库来支持存活的肿瘤细胞。通过这样做，我们的目标是建立一个基础的牵连代谢机制，支持生长和肿瘤的GBM在文献中。由于很少有专门针对GBM代谢途径的治疗干预措施，我们希望这篇综述能进一步深入了解新治疗方式的发展。
Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. With a designation of WHO Grade IV, it is also the most lethal primary brain tumor with a median survival of just 15 months. This is often despite aggressive treatment that includes surgical resection, radiation therapy, and chemotherapy. Based on the poor outcomes and prevalence of the tumor, the demand for innovative therapies continues to represent a pressing issue for clinicians and researchers. In terms of therapies targeting metabolism, the prevalence of the Warburg effect has led to a focus on targeting glucose metabolism to halt tumor progression. While glucose is the dominant source of growth substrate in GBM, a number of unique metabolic pathways are exploited in GBM to meet the increased demand for replication and progression. In this review we aim to explore how metabolites from fatty acid oxidation, the urea cycle, the glutamate-glutamine cycle, and one-carbon metabolism are shunted toward energy producing pathways to meet the high energy demand in GBM. We will also explore how the process of autophagy provides a reservoir of nutrients to support viable tumor cells. By so doing, we aim to establish a foundation of implicated metabolic mechanisms supporting growth and tumorigenesis of GBM within the literature. With the sparse number of therapeutic interventions specifically targeting metabolic pathways in GBM, we hope that this review expands further insight into the development of novel treatment modalities.
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影响因子：
11.2
作者：
Hu YL;DeLay M;Jahangiri A;Molinaro AM;Rose SD;Carbonell WS;Aghi MK
通讯作者：
Aghi MK
影响因子：
29
作者：
Marin-Valencia I;Yang C;Mashimo T;Cho S;Baek H;Yang XL;Rajagopalan KN;Maddie M;Vemireddy V;Zhao Z;Cai L;Good L;Tu BP;Hatanpaa KJ;Mickey BE;Matés JM;Pascual JM;Maher EA;Malloy CR;Deberardinis RJ;Bachoo RM
通讯作者：
Bachoo RM
影响因子：
4.2
作者：
Houten, Sander Michel;Wanders, Ronald J. A.
通讯作者：
Wanders, Ronald J. A.
影响因子：
11.5
作者：
Fink, Matthias A.;Paland, Heiko;Bien-Moeller, Sandra
通讯作者：
Bien-Moeller, Sandra
影响因子：
--
作者：
HIRAYAMA, H;XU, X;PANG, KS
通讯作者：
PANG, KS