Network balance via CRY signalling controls the Arabidopsis circadian clock over ambient temperatures.
Network balance via CRY signalling controls the Arabidopsis circadian clock over ambient temperatures.
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DOI：
10.1038/msb.2013.7
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发表时间：
2013
影响因子：
9.9
通讯作者：
Hall, Anthony J. W.
中科院分区：
文献类型：
--
作者：
Gould, Peter D.;Ugarte, Nicolas;Domijan, Mirela;Costa, Maria;Foreman, Julia;MacGregor, Dana;Rose, Ken;Griffiths, Jayne;Millar, Andrew J.;Finkenstaedt, Baerbel;Penfield, Steven;Rand, David A.;Halliday, Karen J.;Hall, Anthony J. W.
昼夜节律钟表现出“温度补偿”，这意味着它们在很宽的温度范围内只显示很小的周期变化。拟南芥中的几个时钟基因与温度依赖性的周期控制有关。我们发现蓝光对此至关重要，这表明光和温度的影响相互作用或会聚在生物钟中的共同目标上。我们的数据表明，两个隐色素光感受器差异控制昼夜节律周期和维持整个生理温度范围内的节律性。为了验证光调节的目标足以介导温度补偿的假设，我们构建了一个温度补偿时钟模型，通过将被动温度效应添加到模型中的光敏过程中。值得注意的是，该模型不仅能够完全温度补偿并与整个温度范围内的mRNA谱一致，而且还预测了关键时钟蛋白LATE ELLONGATED HYPOCOTYL水平的温度依赖性变化。我们的分析提供了一个系统级的理解周期控制植物昼夜节律振荡器。
Circadian clocks exhibit ‘temperature compensation’, meaning that they show only small changes in period over a broad temperature range. Several clock genes have been implicated in the temperature-dependent control of period in Arabidopsis. We show that blue light is essential for this, suggesting that the effects of light and temperature interact or converge upon common targets in the circadian clock. Our data demonstrate that two cryptochrome photoreceptors differentially control circadian period and sustain rhythmicity across the physiological temperature range. In order to test the hypothesis that the targets of light regulation are sufficient to mediate temperature compensation, we constructed a temperature-compensated clock model by adding passive temperature effects into only the light-sensitive processes in the model. Remarkably, this model was not only capable of full temperature compensation and consistent with mRNA profiles across a temperature range, but also predicted the temperature-dependent change in the level of LATE ELONGATED HYPOCOTYL, a key clock protein. Our analysis provides a systems-level understanding of period control in the plant circadian oscillator.
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影响因子：
11.6
作者：
Baudry, Antoine;Ito, Shogo;Imaizumi, Takato
通讯作者：
Imaizumi, Takato
影响因子：
9.9
作者：
Brettschneider, Christian;Rose, Rebecca J.;Hertel, Stefanie;Axmann, Ilka M.;Heck, Albert J. R.;Kollmann, Markus
通讯作者：
Kollmann, Markus
影响因子：
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影响因子：
56.9
作者：
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通讯作者：
Mas, P.
影响因子：
5.1
作者：
Davis, Amanda M.;Hall, Anthony;Davis, Seth J.
通讯作者：
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