Transmission of avian influenza virus (H3N2) to dogs.
Transmission of avian influenza virus (H3N2) to dogs.
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DOI：
10.3201/eid1405.071471
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发表时间：
2008-05
影响因子：
11.8
通讯作者：
Oh J
中科院分区：
文献类型：
--
作者：
Song D;Kang B;Lee C;Jung K;Ha G;Kang D;Park S;Park B;Oh J
在患有严重呼吸道疾病的宠物犬中发现了该病毒的感染和传播。在韩国，其中禽流感病毒亚型H3 N2、H5 N1、H6 N1和H9 N2正在传播或已被检测到，从表现出严重呼吸道疾病的犬中分离出3种遗传相似的禽源犬流感病毒（H3 N2）毒株（A/canine/Korea/01/2007、A/canine/Korea/02/2007和A/canine/Korea/03/2007）。为了确定禽源性新型犬流感病毒是否在犬之间传播，我们用这种流感病毒（H3 N2）分离株实验性感染了比格犬。比格犬通过鼻分泌物排出病毒，血清转化，并患上严重的坏死性气管支气管炎和细支气管肺泡炎，伴有临床体征（例如，高烧）。与肺部病变的组织学观察结果一致，在犬气管、支气管和细支气管上皮细胞中鉴定出大量禽流感病毒结合受体（SAα 2，3-gal），这表明禽流感病毒（H3 N2）有可能从家禽直接传播给犬。我们的数据提供了证据，表明狗可能在流感病毒的种间传播和传播中发挥作用。
Infection with and transmission of the virus was identified in pet dogs with severe respiratory disease. In South Korea, where avian influenza virus subtypes H3N2, H5N1, H6N1, and H9N2 circulate or have been detected, 3 genetically similar canine influenza virus (H3N2) strains of avian origin (A/canine/Korea/01/2007, A/canine/Korea/02/2007, and A/canine/Korea/03/2007) were isolated from dogs exhibiting severe respiratory disease. To determine whether the novel canine influenza virus of avian origin was transmitted among dogs, we experimentally infected beagles with this influenza virus (H3N2) isolate. The beagles shed virus through nasal excretion, seroconverted, and became ill with severe necrotizing tracheobronchitis and bronchioalveolitis with accompanying clinical signs (e.g., high fever). Consistent with histologic observation of lung lesions, large amounts of avian influenza virus binding receptor (SAα 2,3-gal) were identified in canine tracheal, bronchial, and bronchiolar epithelial cells, which suggests potential for direct transmission of avian influenza virus (H3N2) from poultry to dogs. Our data provide evidence that dogs may play a role in interspecies transmission and spread of influenza virus.
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影响因子：
11.8
作者：
Keawcharoen J;Oraveerakul K;Kuiken T;Fouchier RA;Amonsin A;Payungporn S;Noppornpanth S;Wattanodorn S;Theambooniers A;Tantilertcharoen R;Pattanarangsan R;Arya N;Ratanakorn P;Osterhaus DM;Poovorawan Y
通讯作者：
Poovorawan Y
影响因子：
1.4
作者：
Gibbs, PS;Maurer, JJ;Wooley, RE
通讯作者：
Wooley, RE
影响因子：
1.5
作者：
Song, DS;Lee, JY;Park, BK
通讯作者：
Park, BK
影响因子：
3.7
作者：
WEBSTER, RG;HINSHAW, VS;PETURSSON, G
通讯作者：
PETURSSON, G
影响因子：
11.8
作者：
Webster, RG
通讯作者：
Webster, RG