Insights Into the Regulation of Offspring Growth by Maternally Derived Ghrelin.
Insights Into the Regulation of Offspring Growth by Maternally Derived Ghrelin.
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DOI：
10.3389/fendo.2022.852636
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发表时间：
2022
影响因子：
5.2
通讯作者：
Kojima M
中科院分区：
文献类型：
--
作者：
Sato T;Ida T;Shiimura Y;Matsui K;Oishi K;Kojima M
来自孕母的激素和神经肽等生物活性物质对胎儿发育的调节被认为对胎儿的发育至关重要。另一方面，有研究认为，由于各种因素导致孕母生理状态的变化，可能会改变这些生物活性物质的分泌，诱发后代的代谢变化，如肥胖、暴饮暴食、炎症等，从而影响出生后的生长和健康。然而，我们对母体生物活性物质如何调节后代生理的知识仍然是碎片化的，缺乏系统的理解。在这篇综述中，我们将重点关注调节生长和能量代谢的胃饥饿素，以促进我们对母体衍生的胃饥饿素调节后代生长和健康的机制的理解。了解母源性胃饥饿素对后代生长的调节，有望澄清胎儿代谢异常的发病，并有助于更好地了解下一代后代的终身健康。
The regulation of fetal development by bioactive substances such as hormones and neuropeptides derived from the gestational mother is considered to be essential for the development of the fetus. On the other hand, it has been suggested that changes in the physiological state of the pregnant mother due to various factors may alter the secretion of these bioactive substances and induce metabolic changes in the offspring, such as obesity, overeating, and inflammation, thereby affecting postnatal growth and health. However, our knowledge of how gestational maternal bioactive substances modulate offspring physiology remains fragmented and lacks a systematic understanding. In this mini-review, we focus on ghrelin, which regulates growth and energy metabolism, to advance our understanding of the mechanisms by which maternally derived ghrelin regulates the growth and health of the offspring. Understanding the regulation of offspring growth by maternally-derived ghrelin is expected to clarify the fetal onset of metabolic abnormalities and lead to a better understanding of lifelong health in the next generation of offspring.
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