An Objective Screening Method for Major Depressive Disorder Using Logistic Regression Analysis of Heart Rate Variability Data Obtained in a Mental Task Paradigm.
An Objective Screening Method for Major Depressive Disorder Using Logistic Regression Analysis of Heart Rate Variability Data Obtained in a Mental Task Paradigm.
复制标题
DOI：
10.3389/fpsyt.2016.00180
复制
发表时间：
2016
影响因子：
4.7
通讯作者：
Matsui T
中科院分区：
文献类型：
--
作者：
Sun G;Shinba T;Kirimoto T;Matsui T
心率变异性(HRV)作为一种很有前途的抑郁症生物学标志物已被广泛研究。我们先前的研究证实，在休息和精神任务(MT)条件下，心率变异性显示的自主神经活动和抑郁症的反应性可以作为诊断手段和临床评估。在这项研究中，Logistic回归分析(LRA)被用来根据在MT范式下获得的HRV数据对MDD进行分类和预测。对静冈资生会综合医院精神科44例药物未用药的MDD患者和47例健康对照的R-R间期进行了随机数产生前、中、后的心率变异性功率谱分析。用心率变异性指数和心率测定LRA的Logit评分可区分MDD患者和健康人。心率变异性的高频成分和低频成分与高频成分的比值(LF/HF)分别对应于副交感神经平衡和交感迷走神经平衡。LRA的灵敏度和特异度分别为80.0%和79.0%，最适Logit评分为0.28。只有当Logit分数接近截止分数时，才会发生错误分类。Logit得分与主观抑郁自评量表得分显著相关(p <； 0.05)。在一次MT中记录的HRV指数可能是一种在精神科实践中筛查MDD患者的客观工具。该方法不仅可用于MDD的客观快速筛查，还可用于评估MDD的严重程度。
Heart rate variability (HRV) has been intensively studied as a promising biological marker of major depressive disorder (MDD). Our previous study confirmed that autonomic activity and reactivity in depression revealed by HRV during rest and mental task (MT) conditions can be used as diagnostic measures and in clinical evaluation. In this study, logistic regression analysis (LRA) was utilized for the classification and prediction of MDD based on HRV data obtained in an MT paradigm. Power spectral analysis of HRV on R–R intervals before, during, and after an MT (random number generation) was performed in 44 drug-naïve patients with MDD and 47 healthy control subjects at Department of Psychiatry in Shizuoka Saiseikai General Hospital. Logit scores of LRA determined by HRV indices and heart rates discriminated patients with MDD from healthy subjects. The high frequency (HF) component of HRV and the ratio of the low frequency (LF) component to the HF component (LF/HF) correspond to parasympathetic and sympathovagal balance, respectively. The LRA achieved a sensitivity and specificity of 80.0 and 79.0%, respectively, at an optimum cutoff logit score (0.28). Misclassifications occurred only when the logit score was close to the cutoff score. Logit scores also correlated significantly with subjective self-rating depression scale scores (p < 0.05). HRV indices recorded during a MT may be an objective tool for screening patients with MDD in psychiatric practice. The proposed method appears promising for not only objective and rapid MDD screening but also evaluation of its severity.
登录
查看更多内容
统计评论14：逻辑回归。
影响因子：
15.1
作者：
Bewick, V;Cheek, L;Ball, J
通讯作者：
Ball, J
影响因子：
6.6
作者：
Chen, LS;Eaton, WW;Nestadt, G
通讯作者：
Nestadt, G
影响因子：
11.9
作者：
Shinba, Toshikazu
通讯作者：
Shinba, Toshikazu
影响因子：
6.6
作者：
Udupa, Kaviraja;Sathyaprabha, T. N.;Gangadhar, B. N.
通讯作者：
Gangadhar, B. N.
影响因子：
10.6
作者：
Yeragani, VK;Pesce, V;Roose, S
通讯作者：
Roose, S