The molecular tug of war between immunity and fertility: Emergence of conserved signaling pathways and regulatory mechanisms.
The molecular tug of war between immunity and fertility: Emergence of conserved signaling pathways and regulatory mechanisms.
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免疫和生育能力之间的战争分子拖船：保守的信号通路和调节机制的出现。
DOI：
10.1002/bies.202000103
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Ghazi A
中科院分区：
文献类型：
--
作者：
Naim N;Amrit FRG;McClendon TB;Yanowitz JL;Ghazi A
在大多数生物体中，生殖和免疫是能量密集型的、密切相关的过程。在女性中，怀孕与广泛的免疫适应有关，这些免疫适应改变了对许多疾病的免疫力，而免疫功能障碍已成为男性和女性不育的主要原因。破译这种动态关联的分子基础在哺乳动物中具有固有的挑战性。传统上，这种关系一直在快速生活的无脊椎动物物种中进行研究，通常是在生活史特征之间的资源分配的背景下进行的。最近，这些研究促进了我们对免疫-生育对话机制基础的理解。在这里，我们从人类怀孕的角度，在实验室生物的机制发现，生殖和免疫之间的分子联系。我们特别关注最近的无脊椎动物研究，确定保守的信号通路和转录因子，调节资源分配和塑造生殖状态和免疫健康之间的平衡。
Reproduction and immunity are energy intensive, intimately linked processes in most organisms. In women, pregnancy is associated with widespread immunological adaptations that alter immunity to many diseases, whereas, immune dysfunction has emerged as a major cause for infertility in both men and women. Deciphering the molecular bases of this dynamic association is inherently challenging in mammals. This relationship has been traditionally studied in fast-living, invertebrate species, often in the context of resource allocation between life history traits. More recently, these studies have advanced our understanding of the mechanistic underpinnings of the immunity-fertility dialogue. Here, we review the molecular connections between reproduction and immunity from the perspective of human pregnancy to mechanistic discoveries in laboratory organisms. We focus particularly on recent invertebrate studies identifying conserved signaling pathways and transcription factors that regulate resource allocation and shape the balance between reproductive status and immune health.
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影响因子：
9.2
作者：
Clark, Rebecca I.;Woodcock, Katie J.;Geissmann, Frederic;Trouillet, Celine;Dionne, Marc S.
通讯作者：
Dionne, Marc S.
DOI：
10.1111/aji.12102
发表时间：
2013-06
期刊：
American journal of reproductive immunology (New York, N.Y. : 1989)
影响因子：
--
作者：
Bonney EA
通讯作者：
Bonney EA
影响因子：
3.2
作者：
Bonney EA
通讯作者：
Bonney EA
影响因子：
3.3
作者：
Corsi AK;Wightman B;Chalfie M
通讯作者：
Chalfie M
影响因子：
64.8
作者：
Becker, Thomas;Loch, Gerrit;Hoch, Michael
通讯作者：
Hoch, Michael