Multiple TGF-β superfamily signals modulate the adult Drosophila immune response.
Multiple TGF-β superfamily signals modulate the adult Drosophila immune response.
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DOI：
10.1016/j.cub.2011.08.048
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发表时间：
2011-10-11
期刊：
影响因子：
9.2
通讯作者：
Dionne, Marc S.
中科院分区：
文献类型：
--
作者：
Clark, Rebecca I.;Woodcock, Katie J.;Geissmann, Frederic;Trouillet, Celine;Dionne, Marc S.
TGF-β超家族信号在哺乳动物组织修复和炎症调节中发挥复杂作用。黑腹果蝇是研究先天免疫功能和伤口愈合的良好模型。在此，我们探讨了TGF-β超家族成员dawdle和decapentaplegic （dpp）在成年果蝇损伤和感染反应中的作用和调控。我们发现这两种TGF-β信号在对损伤和感染的反应中都表现出复杂的调节，每种信号都在吞噬细胞的一个子集中表达，每种信号都抑制免疫反应的一个特定臂。DPP被伤口迅速激活并抑制抗菌肽的产生；缺乏DPP功能的果蝇即使在小伤口后也会持续表达强烈的抗菌肽。相比之下，革兰氏阳性细菌感染会激活磨盘菌，但革兰氏阴性细菌感染或损伤会抑制磨盘菌；它的作用是限制感染引起的黑色素化。缺乏磨蹭功能的果蝇即使在未感染的情况下也表现出黑化。总之，这些数据暗示了一个模型，在这个模型中，骨形态发生蛋白（BMP） dpp是无菌损伤后炎症的重要抑制剂，而激活素样的磨盘决定了诱导免疫反应的性质。►BMP和激活素信号对伤口或感染诱导的信号反应不同►BMP和激活素信号抑制苍蝇免疫反应的不同分支►这些信号由血细胞亚群表达
TGF-β superfamily signals play complex roles in regulation of tissue repair and inflammation in mammals. Drosophila melanogaster is a well-established model for the study of innate immune function and wound healing. Here, we explore the role and regulation of two TGF-β superfamily members, dawdle and decapentaplegic (dpp), in response to wounding and infection in adult Drosophila. We find that both TGF-β signals exhibit complex regulation in response to wounding and infection, each is expressed in a subset of phagocytes, and each inhibits a specific arm of the immune response. dpp is rapidly activated by wounds and represses the production of antimicrobial peptides; flies lacking dpp function display persistent, strong antimicrobial peptide expression after even a small wound. dawdle, in contrast, is activated by Gram-positive bacterial infection but repressed by Gram-negative infection or wounding; its role is to limit infection-induced melanization. Flies lacking dawdle function exhibit melanization even when uninfected. Together, these data imply a model in which the bone morphogenetic protein (BMP) dpp is an important inhibitor of inflammation following sterile injury whereas the activin-like dawdle determines the nature of the induced immune response. ► BMP and activin signals respond differently to wound- or infection-induced cues ► BMP and activin signals repress different branches of the fly immune response ► These signals are expressed by subsets of hemocytes
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影响因子：
2.7
作者：
Rämet, M;Lanot, R;Manfruelli, P
通讯作者：
Manfruelli, P
一种调节果蝇呼吸系统中免疫黑素化的SERPIN。
影响因子：
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作者：
Tang, Huaping;Kambris, Zakaria;Lemaitre, Bruno;Hashimoto, Carl
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作者：
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通讯作者：
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