5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms.
5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms.
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5-HT2C（HTR2C）血清素受体基因多态性与奖励依赖的人类人格特征相关：与多巴胺D4受体（D4DR）和多巴胺D3受体（D3DR）多态性的相互作用。
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
R. Belmaker
中科院分区：
文献类型：
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作者：
R. P. Ebstein;R. Segman;J. Benjamin;Y. Osher;L. Nemanov;R. Belmaker
我们最近报告了多巴胺D4外显子III受体多态性的长重复等位基因与人类人格维度（新奇寻求）之间的关联，该维度是通过三维人格问卷（TPQ）测量的，TPQ是Cloninger设计的一种人格工具，旨在反映人类气质的遗传方面。D4受体多态性（D4 DR）仅占该性状方差的一小部分，这表明其他基因既影响新奇寻求，也影响Cloninger TPQ列出的其他气质。在目前的调查中，我们研究了，在原始队列的120名正常志愿者，两个额外的编码区多态性，甘氨酸丝氨酸取代多巴胺D3受体（D3 DR）和半胱氨酸丝氨酸取代5-HT 2C 5-羟色胺受体（HTR 2C）。三因素方差分析（TPQ得分分组D4 DR，D3 DR和5-HT 2C）表明，奖励依赖性和持久性得分显着降低了不太常见的5-HT 2Cser多态性的存在。当分别分析男性和女性受试者组时，还观察到X连锁5-羟色胺受体多态性中丝氨酸取代对奖励依赖的影响。两种多巴胺受体多态性和5-羟色胺多态性在奖赏依赖上也存在显著的交互作用。特别是，奖励依赖的5-HT 2C多态性的效果显着加重的个人谁拥有长版本的D4 DR外显子III重复多态性。当存在于同一个体中时，5-HT 2C和多巴胺受体多态性占观察到的持久性方差（RD 2）的30%，占奖励依赖评分方差的13%（RD 134）。然而，同时具有不太常见的D4 DR和5-HT 2C多态性的受试者数量很少，这强调了在更大的队列中验证这种相互作用的重要性。
We recently reported an association between the long repeat allele of the dopamine D4 exon III receptor polymorphism and a human personality dimension, novelty seeking, as measured by the tridimensional personality questionnaire (TPQ), a personality instrument designed by Cloninger to reflect heritable facets of human temperament. The D4 receptor polymorphism (D4DR) accounts for only a small percent of the variance for this trait, suggesting that additional genes influence both novelty seeking as well as the other temperaments that are inventoried by the Cloninger TPQ. In the current investigation, we examined, in the original cohort of 120 normal volunteers, two additional coding region polymorphisms, a glycine to serine substitution in the dopamine D3 receptor (D3DR) and a cysteine to serine substitution in the 5-HT2C serotonin receptor (HTR2C). Three-way analysis of variance (TPQ score grouped by D4DR, D3DR and 5-HT2C) demonstrated that reward dependence and persistence scores were significantly reduced by the presence of the less common 5-HT2Cser polymorphism. The effect of the serine substitution in this X-linked serotonin receptor polymorphism on reward dependence was also observed when male and female subject groups were separately analyzed. There was also a significant interaction between the two dopamine receptor polymorphisms and the serotonin polymorphism on reward dependence. In particular, the effect of the 5-HT2C polymorphism on reward dependence was markedly accentuated in individuals who had the long version of the D4DR exon III repeat polymorphism. When present in the same individual, the 5-HT2C and dopamine receptor polymorphisms account for 30% of the observed variance for persistence (RD2) and 13% of the variance for reward dependence scores (RD134). However, the number of subjects with both less common D4DR and 5-HT2C polymorphisms is small, underscoring the importance of verifying this interaction in a larger cohort.
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通过气质和性格七因素模型鉴别诊断人格障碍。
影响因子：
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作者：
Svrakic,DM;Whitehead,C;Przybeck,TR;Cloninger,CR
通讯作者：
Cloninger,CR
影响因子：
56.9
作者：
PLOMIN, R;OWEN, MJ;MCGUFFIN, P
通讯作者：
MCGUFFIN, P
影响因子：
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作者：
CLONINGER, CR;SVRAKIC, DM;PRZYBECK, TR
通讯作者：
PRZYBECK, TR
影响因子：
56.9
作者：
CAINE, SB;KOOB, GF
通讯作者：
KOOB, GF