Visual cortex activation to drug cues: a meta-analysis of functional neuroimaging papers in addiction and substance abuse literature.
Visual cortex activation to drug cues: a meta-analysis of functional neuroimaging papers in addiction and substance abuse literature.
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DOI：
10.1016/j.drugalcdep.2014.07.028
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发表时间：
2014-10-01
影响因子：
4.2
通讯作者：
Cortese, Bernadette M.
中科院分区：
文献类型：
--
作者：
Hanlon, Colleen A.;Dowdle, Logan T.;Naselaris, Thomas;Canterberry, Melanie;Cortese, Bernadette M.
尽管视觉皮质在成瘾文献中通常不会受到太多关注，但神经成像研究经常报告，当吸毒者接触药物线索时，视觉区域会出现显着活动。这项荟萃分析的目的是调查的频率与枕叶皮质活动观察药物线索暴露期间，并确定其空间分布。对药物线索反应性的人类功能神经影像学研究进行了全面的文献检索。55项研究被用来确定在视觉药物线索与非药物线索期间显著的视觉皮层活动集群的频率。在这些研究的一个子集（n=24）中，通过激活似然估计（ALE; FDR校正，p<0.01）确定视觉皮层激活的空间分布。在药物依赖组中，86%的研究报告了药物与中性视觉线索的功能磁共振成像结果，显示了药物引起的视觉皮层活动。ALE揭示了左侧次级视觉皮层（BA 19）和初级视觉皮层（BA 17）中的簇，这些簇始终被药物线索激活。这些数据表明，在我们对成瘾神经回路的讨论中经常被忽视的视觉皮层，在物质依赖人群中始终区分药物线索和中性线索。虽然目前尚不清楚药物线索引起的枕叶皮层激活是否与药物和/或注意力机制的奖励特性有关，但这些数据支持进一步探索。
Although the visual cortex does not typically receive much attention in addiction literature, neuroimaging studies often report significant activity in visual areas when drug users are exposed to drug cues. The purpose of this meta-analysis was to investigate the frequency with which occipital cortex activity is observed during drug cue exposure and to determine its spatial distribution. A comprehensive literature search was performed of human functional neuroimaging studies of drug cue-reactivity. Fifty-five studies were used to determine the frequency with which clusters of significant visual cortex activity during visual drug cues versus non-drug cues were reported. The spatial distribution of visual cortex activations was determined via activation likelihood estimation (ALE; FDR corrected, p<0.01) in a subset of these studies (n=24). Eighty-six percent of studies that reported fMRI results for drug versus neutral visual cues within a substance-dependent group showed significant drug-elicited activity in the visual cortex. ALE revealed clusters in the left secondary visual cortex (BA 19) and clusters in the primary visual cortex (BA 17) that were consistently activated by drug cues. These data demonstrate that the visual cortex, often overlooked in our discussions of the neural circuitry of addiction, consistently discriminates drug cues from neutral cues in substance dependent populations. While it remains unclear whether drug cue-elicited activation in occipital cortex is related to the rewarding properties of the drug and/or attentional mechanisms, these data support further exploration.
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影响因子：
6
作者：
Carter, BL;Tiffany, ST
通讯作者：
Tiffany, ST
影响因子：
4.2
作者：
Ataya, Alia F.;Adams, Sally;Munafo, Marcus R.
通讯作者：
Munafo, Marcus R.
DOI：
10.1073/pnas.0903863106
发表时间：
2009-08-04
影响因子：
11.1
作者：
Filbey, Francesca M.;Schacht, Joseph P.;Hutchison, Kent E.
通讯作者：
Hutchison, Kent E.
影响因子：
4.2
作者：
Field, Matt;Eastwood, Brian;Mogg, Karin
通讯作者：
Mogg, Karin
影响因子：
10.6
作者：
Chase HW;Eickhoff SB;Laird AR;Hogarth L
通讯作者：
Hogarth L