A Systematic Review of Household and Family Alcohol Use and Childhood Neurodevelopmental Outcomes in Low- and Middle-Income Countries.
A Systematic Review of Household and Family Alcohol Use and Childhood Neurodevelopmental Outcomes in Low- and Middle-Income Countries.
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DOI：
10.1007/s10578-020-01112-3
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发表时间：
2021-12
影响因子：
2.9
通讯作者：
Davidson LL
中科院分区：
文献类型：
--
作者：
Huq T;Alexander EC;Manikam L;Jokinen T;Patil P;Benjumea D;Das I;Davidson LL
儿童期暴露于家庭成年人滥用酒精与儿童发育迟缓，认知影响，精神疾病和问题行为有关。大多数证据来自高收入国家。该系统性综述仅纳入了来自低收入和中等收入国家（LMIC）的研究。检索了1990-2020年的5个数据库。纳入了28项针对0-12岁儿童的研究，共有来自11个LMIC的42，599名参与者。最常见的结局是行为问题/障碍（19项研究）。尽管不同的研究设计，本次审查发现，酒精滥用的家庭成员在中低收入国家与不利的儿童神经发育的结果，虽然不经意的推论不能得出在没有良好的前瞻性研究。统计学显着的相关性被描述为父母酗酒和儿童的情绪和行为困难，认知延迟，和危险行为。未来，建议进行前瞻性队列研究，并对混杂因素进行调整。在线版本包含补充材料，可通过10.1007/s10578-020-01112-3获得。
Childhood exposure to alcohol misuse by household adults has been related to childhood developmental delay, cognitive impacts, mental illness, and problem behaviours. Most evidence comes from high income countries. This systematic review only included studies from low- and middle-income countries (LMICs). Five databases were searched from 1990–2020. Twenty-eight studies of children 0–12 years were included, with 42,599 participants from 11 LMICs. The most common outcome was behavioural problems/disorders (19 studies). Despite varying study designs, this review found that alcohol misuse by household members in LMICs is associated with adverse child neurodevelopmental outcomes, although casual inferences cannot be drawn in the absence of well conducted prospective studies. Statistically significant correlations were described between parental alcohol misuse and child emotional and behavioural difficulties, cognitive delay, and risky behaviours. In future, prospective cohort studies are recommended, with adjustment for confounders. The online version contains supplementary material available at 10.1007/s10578-020-01112-3.
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