Altered Lymphatic Vessel Anatomy and Markedly Diminished Lymph Clearance in Affected Hands of Patients With Active Rheumatoid Arthritis.
Altered Lymphatic Vessel Anatomy and Markedly Diminished Lymph Clearance in Affected Hands of Patients With Active Rheumatoid Arthritis.
复制标题
DOI：
10.1002/art.41311
复制
发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Ritchlin CT
中科院分区：
文献类型：
--
作者：
Bell RD;Rahimi H;Kenney HM;Lieberman AA;Wood RW;Schwarz EM;Ritchlin CT
通过近红外吲哚青绿(NIR-ICG)成像评估活动期滑膜炎RA手与健康对照(CTL)手淋巴功能的差异。对13例CTL和8例活动期RA患者(DAS28>4.4)进行了100μMICG0.1mlNIR成像。在初始注射后7±1天，通过近红外成像测定ICG从网腔中滞留的百分比；图像分析提供收缩频率。ICG+LV长度和分支架构。与CTL相比，RA手的ICG保留率增加(84±28%比53±19%；p<；0.01)。CTL组和RA组ICG+LV平均收缩频率分别为0.51±0.35和0.53±0.39次/min，差异无统计学意义。RA患者ICG+LV总长度减少(58·3±15·0vs.71·4±16·1 cm，P<0·05)，ICG+基本LV数目减少(P<0·05)。与对照组相比，活动期RA患者手部淋巴引流减少。这种减少与手背表面ICG+LV总长度减少有关，手背表面ICG+LV的收缩速度与对照组相似。这些发现为滑膜炎和关节损伤的恶化提供了一个可信的机制。具体地说，由于传出淋巴流受损，炎症细胞和分解代谢因子在RA关节中积聚和滞留。在未来的临床试验中，RA手的NIR-ICG成像是可行的，并值得进行正式研究，作为关节炎疾病严重程度和/或持久性的主要结果衡量标准。
Assess differences in lymphatic function of RA hands with active synovitis versus healthy controls (Ctl) via near infrared-indocyanine green (NIR-ICG) imaging. NIR imaging of 13 Ctl and 8 RA subjects with active disease (DAS28 > 4.4) was performed following web space injection of 0.1ml of 100μM ICG. Percent ICG retention from the web spaces was determined via NIR imaging at baseline and 7±1 day after the initial injections; image analysis provided contraction frequency. ICG+ LV length and branching architecture. Retention of ICG in RA hands increased compared to Ctl (84±28% vs. 53±19% respectively; p<0.01). The average contraction frequency in ICG+ LV between Ctl and RA subjects (0.51±0.35 vs 0.53±0.39 contractions/min) did not differ. Total ICG+ LV length in RA hands was reduced (58.3±15.0 vs. 71.4±16.1cm; p<0.001), concomitant with a decrease in the number ICG+ basilic-LVs vs. Ctl (p<0.05). Lymphatic drainage in the hands of RA patients with active disease was reduced compared to controls. This reduction was associated with less total length of ICG+ LVs on the dorsal surface of the hands, which continued to contract at a similar rate to controls. These findings provide a plausible mechanism for exacerbation of synovitis and joint damage. Specifically, the accumulation and retention of inflammatory cells and catabolic factors in RA joints due to impaired efferent lymphatic flow. NIR-ICG imaging of RA hands is feasible and warrants formal investigation as a primary outcome measure of arthritis disease severity and/or persistence in future clinical trials.
登录
查看更多内容
影响因子：
3.7
作者：
Bouta EM;Ju Y;Rahimi H;de Mesy-Bentley KL;Wood RW;Xing L;Schwarz EM
通讯作者：
Schwarz EM
影响因子：
2.2
作者：
Harrell, Maria I.;Iritani, Brian M.;Ruddell, Alanna
通讯作者：
Ruddell, Alanna
影响因子：
16.6
作者：
Ji, Hong;Cao, Renhai;Cao, Yihai
通讯作者：
Cao, Yihai
影响因子：
27.4
作者：
Polzer, K.;Baeten, D.;Zwerina, J.
通讯作者：
Zwerina, J.
将淋巴功能作为类风湿关节炎的新型治疗干预措施。
DOI：
10.1038/nrrheum.2017.205
发表时间：
2018-03
期刊：
Nature reviews. Rheumatology
影响因子：
--
作者：
Bouta EM;Bell RD;Rahimi H;Xing L;Wood RW;Bingham CO 3rd;Ritchlin CT;Schwarz EM
通讯作者：
Schwarz EM