Higher serum folate levels are associated with a lower risk of atopy and wheeze.
Higher serum folate levels are associated with a lower risk of atopy and wheeze.
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DOI：
10.1016/j.jaci.2009.03.007
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发表时间：
2009-06
影响因子：
14.2
通讯作者：
Matsui, William
中科院分区：
文献类型：
--
作者：
Matsui, Elizabeth C.;Matsui, William
关键词：
Folic acid is known to be associated with inflammatory diseases, but the relationship between folic acid and allergic diseases is unclear. The purpose of the study was to examine the relationship between serum folate levels and markers of atopy, wheeze, and asthma. Data were obtained from the 2005–2006 National Health and Nutrition Examination Survey (NHANES) in which serum folate and total IgE levels were measured in 8,083 subjects 2 years of age and older. A high total IgE level was defined as >100kU/L. Allergen-specific IgE levels were measured for a panel of 5 common aeroallergens. Atopy was defined as at least 1 positive allergen-specific IgE level. Doctor-diagnosed asthma and wheeze in the previous 12 months were assessed by questionnaire. Serum folate levels were inversely associated with total IgE levels (p<.001). The odds of a high total IgE, atopy, and wheeze decreased across quintiles of serum folate, indicating a dose-response relationship between serum folate levels and these outcomes. Each of these associations remained statistically significant after adjusting for age, sex, race/ethnicity and poverty index ratio. Adjusted odds ratios[95% confidence intervals] associated with the fifth quintile (Q5) of folate relative to the first quintile (Q1) were as follows: High IgE: 0.70[0.53–0.92]; atopy: 0.69[0.57–0.85]; and wheeze: 0.60[0.44–0.82]. Higher folate levels were also associated with a lower risk of doctor-diagnosed asthma, but this finding was not statistically significant (OR[95% CI] for Q5 vs. Q1: 0.84 [0.70–1.02]). Serum folate levels are inversely associated with high total IgE, atopy, and wheeze. Folic acid status may influence the development and/or progression of atopy and wheeze.
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DOI：
10.1073/pnas.062066299
发表时间：
2002-04-16
影响因子：
11.1
作者：
Friso, S;Choi, SW;Selhub, J
通讯作者：
Selhub, J
影响因子：
2.1
作者：
Kurzawski, Mateusz;Pawlik, Andrzej;Drozdzik, Marek
通讯作者：
Drozdzik, Marek
影响因子：
5.2
作者：
Håberg SE;London SJ;Stigum H;Nafstad P;Nystad W
通讯作者：
Nystad W
影响因子：
14.2
作者：
Kattan, Meyer;Gergen, Peter J.;Mitchell, Herman E.
通讯作者：
Mitchell, Herman E.
影响因子：
14.2
作者：
Linehan, Mary F.;Frank, Timothy L.;Niven, Robert M.
通讯作者：
Niven, Robert M.