Folic acid supplements in pregnancy and early childhood respiratory health.
Folic acid supplements in pregnancy and early childhood respiratory health.
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DOI：
10.1136/adc.2008.142448
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发表时间：
2009-03
影响因子：
5.2
通讯作者：
Nystad W
中科院分区：
文献类型：
--
作者：
Håberg SE;London SJ;Stigum H;Nafstad P;Nystad W
建议孕妇补充叶酸以降低先天性畸形的风险。母亲在怀孕期间摄入叶酸补充剂也可能通过表观遗传机制影响儿童免疫表型。研究妊娠期补充叶酸与18个月以下儿童下呼吸道感染和喘息风险的关系。在挪威母亲和儿童队列研究中，从2000年至2005年出生的32，077名儿童中在怀孕和出生后的几个时间点收集的问卷数据被用于评估怀孕期间叶酸补充剂对18个月内呼吸结果的影响，考虑了怀孕期间的其他补充剂和婴儿期的补充剂。在妊娠早期补充叶酸与18个月以下喘息和呼吸道感染的风险增加有关。调整怀孕后期和婴儿期的暴露，在怀孕早期暴露于叶酸补充剂的儿童发生喘息的相对危险度为1.06（95%可信区间：1.03，1.10），下呼吸道感染的相对危险度为1.09（95%置信区间：1.02，1.15），下呼吸道感染住院的相对危险度为1.24（95%置信区间：1.09，1.41）。在怀孕期间补充叶酸与18个月大之前喘息和下呼吸道感染的风险略有增加有关。结果支持可能的表观遗传影响的甲基捐助者在母亲的饮食在怀孕期间对儿童的呼吸系统健康。
Folate supplementation is recommended for pregnant women to reduce the risk of congenital malformations. Maternal intake of folate supplements during pregnancy might also influence childhood immune phenotypes via epigenetic mechanisms. To investigate the relationship between folate supplements in pregnancy and risk of lower respiratory tract infections and wheeze in children through 18 months of age. In the Norwegian Mother and Child Cohort Study, questionnaire data collected at several time points in pregnancy and after birth, from 32,077 children born between 2000 and 2005, were used to assess effects of folate supplements during pregnancy on respiratory outcomes up to 18 months of age, accounting for other supplements in pregnancy and supplementation in infancy. Folate supplements in the first trimester were associated with increased risk of wheeze and respiratory tract infections up to 18 months of age. Adjusting for exposure later in pregnancy and in infancy, the relative risk of wheeze for children exposed to folic acid supplements in the first trimester was 1.06 (95% confidence interval: 1.03, 1.10), for lower respiratory tract infections the relative risk was 1.09 (95% confidence interval: 1.02, 1.15), and for hospitalizations for lower respiratory tract infections the relative risk was 1.24 (95% confidence interval: 1.09, 1.41). Folic acid supplements in pregnancy were associated with a slightly increased risk of wheeze and lower respiratory tract infections up to 18 months of age. Results support possible epigenetic influences of methyl donors in maternal diet during pregnancy on respiratory health in children.
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影响因子：
3.9
作者：
Brantsaeter, Anne Lise;Haugen, Margaretha;Meltzer, Helle Margrete
通讯作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
Kulik, RF