Cardiovascular consequences of maternal obesity throughout the lifespan in first generation sheep.
Cardiovascular consequences of maternal obesity throughout the lifespan in first generation sheep.
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DOI：
10.1371/journal.pone.0274214
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Ford, Stephen P.
中科院分区：
文献类型：
--
作者：
Pankey, Christopher L.;Wang, Qiurong;King, Jessica;Ford, Stephen P.
肥胖仍然是一个重要的全球健康问题，并导致各种合并症和疾病状态。重要的是，肥胖会导致不良的心血管健康结果，这是全球死亡的主要原因。此外，妊娠期母亲肥胖已被证明易使后代发生不良表型结局，特别是心血管结局。因此，我们假设妊娠期饮食诱导的肥胖会导致第一代后代的不良心血管表型，这将对青少年和老年人的功能产生影响。从受孕前60天至妊娠第135天（90%）尸检（CON：n = 5，OB：n = 6），或至羔羊足月（F1：2.5 mo），以国家研究理事会建议的100%（CON）或150%（OB）饲喂经产朗布依埃/哥伦比亚杂交母羊（F0）。年龄; CON：n = 9，OB：n = 6）和母羊（F1：9岁; CON：n = 5，OB：n = 8）。石蜡包埋的胎儿主动脉切片染色显示OBF 1胎儿胶原蛋白：弹性蛋白比例增加，主动脉壁厚度增加。侵入性耳血压记录显示，OBF 1羔羊的收缩压升高，但舒张压没有差异。在老年F1母羊，收缩压和舒张压降低OBF 1相对于CONF 1。超声心动图显示F1羔羊无治疗差异，但F1母羊显示收缩末期容积增加和每搏输出量减少的趋势，射血分数显著降低。因此，我们得出结论，母亲肥胖计划改变了心血管的发展，导致高血压状态的OBF 1羔羊。早期高血压导致的心脏工作负荷增加，预示着心脏在以后的生活中无法维持功能。
Obesity continues to be a significant global health issue and contributes to a variety of comorbidities and disease states. Importantly, obesity contributes to adverse cardiovascular health outcomes, which is the leading cause of death worldwide. Further, maternal obesity during gestation has been shown to predispose offspring to adverse phenotypic outcomes, specifically cardiovascular outcomes. Therefore, we hypothesized that diet-induced obesity during gestation would result in adverse cardiovascular phenotypes in first-generation offspring that would have functional consequences in juvenile and advanced ages. Multiparous Rambouillet/Columbia cross ewes (F0) were fed a highly palatable, pelleted diet at either 100% (CON), or 150% (OB) of National Research Council recommendations from 60 days prior to conception, until necropsy at d 135 (90%) of gestation (CON: n = 5, OB: n = 6), or through term for lambs (F1: 2.5 mo. old; CON: n = 9, OB: n = 6) and ewes (F1:9 years old; CON: n = 5, OB: n = 8). Paraffin-embedded fetal aorta section staining revealed increased collagen:elastin ratio and greater aortic wall thickness in OBF1 fetuses. Invasive auricular blood pressure recordings revealed elevated systolic blood pressure in OBF1 lambs, but no differences in diastolic pressure. In aged F1 ewes, systolic and diastolic blood pressures were reduced in OBF1 relative to CONF1. Echocardiography revealed no treatment differences in F1 lambs, but F1 ewes show tendencies for increased end systolic volume and decreased stroke volume, and markedly reduced ejection fraction. Therefore, we conclude that maternal obesity programs altered cardiovascular development that results in a hypertensive state in OBF1 lambs. Increased cardiac workload resulting from early life hypertension precedes the failure of the heart to maintain function later in life.
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DOI：
10.1136/bmj.f4539
发表时间：
2013-08-13
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Reynolds RM;Allan KM;Raja EA;Bhattacharya S;McNeill G;Hannaford PC;Sarwar N;Lee AJ;Bhattacharya S;Norman JE
通讯作者：
Norman JE
影响因子：
3.7
作者：
Ghnenis AB;Odhiambo JF;McCormick RJ;Nathanielsz PW;Ford SP
通讯作者：
Ford SP
DOI：
10.3390/ijerph17186926
发表时间：
2020-09-22
影响因子：
--
作者：
Odhiambo JF;Pankey CL;Ghnenis AB;Ford SP
通讯作者：
Ford SP
DOI：
10.1111/j.1742-7843.2007.00186.x
发表时间：
2008-02-01
影响因子：
3.1
作者：
Hanson, Mark A.;Gluckman, Peter D.
通讯作者：
Gluckman, Peter D.
影响因子：
5.6
作者：
Fan, Xiujuan;Turdi, Subat;Ford, Stephen P.;Hua, Yinan;Nijland, Mark J.;Zhu, Meijun;Nathanielsz, Peter W.;Ren, Jun
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Ren, Jun