Enhanced characterization of the smell of death by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GCxGC-TOFMS).
Enhanced characterization of the smell of death by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GCxGC-TOFMS).
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DOI：
10.1371/journal.pone.0039005
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Focant JF
中科院分区：
文献类型：
--
作者：
Dekeirsschieter J;Stefanuto PH;Brasseur C;Haubruge E;Focant JF
死亡后不久，哺乳动物软组织的腐烂过程开始，并导致周围环境中释放尸体挥发性化合物。尸体分解产物的研究是法医学中一个新兴的研究领域。然而，更好地了解死亡的气味及其挥发性成分可能在法医学中有许多应用。家猪是法医实验中使用最广泛的人体模拟物，主要是由于伦理道德的限制。事实上，在世界上许多国家，对人类尸体的分解试验受到限制。本文报道了使用全面的二维气相色谱-飞行时间质谱联用技术（GCxGC-TOFMS）的死亡化学应用。采用气相色谱-飞行时间质谱联用技术（GCxGC-TOFMS）对森林生态单元中腐烂猪尸体释放的832种VOCs进行了分析。这些死后化合物属于多种化学类别，主要有含氧化合物（醇、酸、酮、醛、酯）、硫和氮化合物、芳香族化合物如酚类分子和烃类。用GCxGC-TOFMS代替传统的GC-MS对尸体挥发性化合物进行研究是成功的。
Soon after death, the decay process of mammalian soft tissues begins and leads to the release of cadaveric volatile compounds in the surrounding environment. The study of postmortem decomposition products is an emerging field of study in forensic science. However, a better knowledge of the smell of death and its volatile constituents may have many applications in forensic sciences. Domestic pigs are the most widely used human body analogues in forensic experiments, mainly due to ethical restrictions. Indeed, decomposition trials on human corpses are restricted in many countries worldwide. This article reports on the use of comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GCxGC-TOFMS) for thanatochemistry applications. A total of 832 VOCs released by a decaying pig carcass in terrestrial ecosystem, i.e. a forest biotope, were identified by GCxGC-TOFMS. These postmortem compounds belong to many kinds of chemical class, mainly oxygen compounds (alcohols, acids, ketones, aldehydes, esters), sulfur and nitrogen compounds, aromatic compounds such as phenolic molecules and hydrocarbons. The use of GCxGC-TOFMS in study of postmortem volatile compounds instead of conventional GC-MS was successful.
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