fsi zebrafish show concordant reversal of laterality of viscera, neuroanatomy, and a subset of behavioral responses.
fsi zebrafish show concordant reversal of laterality of viscera, neuroanatomy, and a subset of behavioral responses.
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DOI：
10.1016/j.cub.2005.03.047
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发表时间：
2005-05-10
期刊：
影响因子：
9.2
通讯作者：
Andrew, RJ
中科院分区：
文献类型：
--
作者：
Barth, KA;Miklosi, A;Watkins, J;Bianco, IH;Wilson, SW;Andrew, RJ
CNS神经解剖学的不对称性被认为是脊椎动物广泛存在的认知和行为不对称性的基础。对人类的研究表明，某些认知不对称的偏侧性与内脏的偏侧性无关;因此，离散机制可能会调节内脏和神经的偏侧化。然而，通过对斑马鱼的内脏、神经解剖学和行为不对称的分析，我们发现主要的左右身体不对称与某些大脑不对称和偏侧行为有关。具有不对称缺陷的FSI鱼显示出间脑中心脏、肠和神经解剖学不对称的一致逆转。此外，反向fsi鱼的神经解剖学反转与鱼苗和成鱼的一些行为反应的反转相关。令人惊讶的是，两个行为不对称不逆转，这表明至少有两个可分离的机制必须影响中枢神经系统的功能偏侧化。部分逆转中枢神经系统的不对称性可能会产生新的行为表型，支持这一观点，扭转fsi鱼苗显着不同，从他们的正常偏侧的兄弟姐妹在他们的行为反应的一种新的视觉功能。我们的研究揭示了内脏和大脑的不对称性与偏侧化行为之间的联系，有助于解释内脏和神经不对称性的偏侧化之间关系的复杂性。
Asymmetries in CNS neuroanatomy are assumed to underlie the widespread cognitive and behavioral asymmetries in vertebrates. Studies in humans have shown that the laterality of some cognitive asymmetries is independent of the laterality of the viscera; discrete mechanisms may therefore regulate visceral and neural lateralization. However, through analysis of visceral, neuroanatomical, and behavioral asymmetries in the frequent-situs-inversus (fsi) line of zebrafish, we show that the principal left-right body asymmetries are coupled to certain brain asymmetries and lateralized behaviors. fsi fish with asymmetry defects show concordant reversal of heart, gut, and neuroanatomical asymmetries in the diencephalon. Moreover, the neuroanatomical reversals in reversed fsi fish correlate with reversal of some behavioral responses in both fry and adult fsi fish. Surprisingly, two behavioral asymmetries do not reverse, suggesting that at least two separable mechanisms must influence functional lateralization in the CNS. Partial reversal of CNS asymmetries may generate new behavioral phenotypes; supporting this idea, reversed fsi fry differ markedly from their normally lateralized siblings in their behavioral response to a novel visual feature. Revealing a link between visceral and brain asymmetry and lateralized behavior, our studies help to explain the complexity of the relationship between the lateralities of visceral and neural asymmetries.
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